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Mendeley readers
Attention Score in Context
| Title |
The special Sm core structure of the U7 snRNP: far-reaching significance of a small nuclear ribonucleoprotein
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, October 2004
|
| DOI | 10.1007/s00018-004-4190-0 |
| Pubmed ID | |
| Authors |
D. Schümperli, R. S. Pillai |
| Abstract |
The polypeptide composition of the U7 small nuclear ribonucleoprotein (snRNP) involved in histone messenger RNA (mRNA) 3' end formation has recently been elucidated. In contrast to spliceosomal snRNPs, which contain a ring-shaped assembly of seven so-called Sm proteins, in the U7 snRNP the Sm proteins D1 and D2 are replaced by U7-specific Sm-like proteins, Lsm10 and Lsm11. This polypeptide composition and the unusual structure of Lsm11, which plays a role in histone RNA processing, represent new themes in the biology of Sm/Lsm proteins. Moreover this structure has important consequences for snRNP assembly that is mediated by two complexes containing the PRMT5 methyltransferase and the SMN (survival of motor neurons) protein, respectively. Finally, the ability to alter this polypeptide composition by a small mutation in U7 snRNA forms the basis for using modified U7 snRNA derivatives to alter specific pre-mRNA splicing events, thereby opening up a new way for antisense gene therapy. |
Mendeley readers
The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 1% |
| Austria | 1 | 1% |
| Sweden | 1 | 1% |
| Spain | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 95 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 23% |
| Researcher | 17 | 17% |
| Student > Bachelor | 12 | 12% |
| Student > Master | 7 | 7% |
| Professor | 6 | 6% |
| Other | 15 | 15% |
| Unknown | 20 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 39 | 39% |
| Biochemistry, Genetics and Molecular Biology | 22 | 22% |
| Medicine and Dentistry | 6 | 6% |
| Neuroscience | 5 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Other | 4 | 4% |
| Unknown | 22 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2023.
All research outputs
#2,605,950
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#363
of 4,151 outputs
Outputs of similar age
#3,978
of 62,443 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#3
of 23 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 62,443 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.