Title |
Mammary stem cells, self-renewal pathways, and carcinogenesis
|
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Published in |
Breast Cancer Research, March 2005
|
DOI | 10.1186/bcr1021 |
Pubmed ID | |
Authors |
Suling Liu, Gabriela Dontu, Max S Wicha |
Abstract |
The mammary gland epithelial components are thought to arise from stem cells that undergo both self-renewal and differentiation. Self-renewal has been shown to be regulated by the Hedgehog, Notch, and Wnt pathways and the transcription factor B lymphoma Mo-MLV insertion region 1 (Bmi-1). We review data about the existence of stem cells in the mammary gland and the pathways regulating the self-renewal of these cells. We present evidence that deregulation of the self-renewal in stem cells/progenitors might be a key event in mammary carcinogenesis. If 'tumor stem cells' are inherently resistant to current therapies, targeting stem cell self-renewal pathways might provide a novel approach for breast cancer treatment. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 5 | 2% |
United States | 5 | 2% |
Canada | 4 | 1% |
India | 1 | <1% |
Iran, Islamic Republic of | 1 | <1% |
Sweden | 1 | <1% |
Japan | 1 | <1% |
Argentina | 1 | <1% |
Unknown | 261 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 56 | 20% |
Student > Ph. D. Student | 53 | 19% |
Researcher | 52 | 19% |
Student > Bachelor | 22 | 8% |
Student > Doctoral Student | 13 | 5% |
Other | 46 | 16% |
Unknown | 38 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 99 | 35% |
Biochemistry, Genetics and Molecular Biology | 52 | 19% |
Medicine and Dentistry | 41 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 11 | 4% |
Engineering | 7 | 3% |
Other | 25 | 9% |
Unknown | 45 | 16% |