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Mendeley readers
Attention Score in Context
| Title |
Deoxygedunin, a Natural Product with Potent Neurotrophic Activity in Mice
|
|---|---|
| Published in |
PLOS ONE, July 2010
|
| DOI | 10.1371/journal.pone.0011528 |
| Pubmed ID | |
| Authors |
Sung-Wuk Jang, Xia Liu, Chi Bun Chan, Stefan A. France, Iqbal Sayeed, Wenxue Tang, Xi Lin, Ge Xiao, Raul Andero, Qiang Chang, Kerry J. Ressler, Keqiang Ye |
| Abstract |
Gedunin, a family of natural products from the Indian neem tree, possess a variety of biological activities. Here we report the discovery of deoxygedunin, which activates the mouse TrkB receptor and its downstream signaling cascades. Deoxygedunin is orally available and activates TrkB in mouse brain in a BDNF-independent way. Strikingly, it prevents the degeneration of vestibular ganglion in BDNF -/- pups. Moreover, deoxygedunin robustly protects rat neurons from cell death in a TrkB-dependent manner. Further, administration of deoxygedunin into mice displays potent neuroprotective, anti-depressant and learning enhancement effects, all of which are mediated by the TrkB receptor. Hence, deoxygedunin imitates BDNF's biological activities through activating TrkB, providing a powerful therapeutic tool for treatment of various neurological diseases. |
Mendeley readers
The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| India | 1 | <1% |
| United States | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 99 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 25% |
| Researcher | 20 | 19% |
| Student > Master | 16 | 16% |
| Professor > Associate Professor | 6 | 6% |
| Student > Bachelor | 5 | 5% |
| Other | 13 | 13% |
| Unknown | 17 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 33 | 32% |
| Chemistry | 13 | 13% |
| Medicine and Dentistry | 10 | 10% |
| Neuroscience | 8 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 6% |
| Other | 14 | 14% |
| Unknown | 19 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 August 2021.
All research outputs
#3,272,020
of 22,786,691 outputs
Outputs from PLOS ONE
#43,034
of 194,517 outputs
Outputs of similar age
#12,715
of 94,849 outputs
Outputs of similar age from PLOS ONE
#197
of 719 outputs
Altmetric has tracked 22,786,691 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 194,517 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,849 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 719 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.