Title |
Similarities and differences in structure, expression, and functions of VLDLR and ApoER2
|
---|---|
Published in |
Molecular Neurodegeneration, May 2011
|
DOI | 10.1186/1750-1326-6-30 |
Pubmed ID | |
Authors |
Sunil S Reddy, Teal E Connor, Edwin J Weeber, William Rebeck |
Abstract |
Very Low Density Lipoprotein Receptor (VLDLR) and Apolipoprotein E Receptor 2 (ApoER2) are important receptors in the brain for mediating the signaling effects of the extracellular matrix protein Reelin, affecting neuronal function in development and in the adult brain. VLDLR and ApoER2 are members of the low density lipoprotein family, which also mediates the effects of numerous other extracellular ligands, including apolipoprotein E. Although VLDLR and ApoER2 are highly homologous, they differ in a number of ways, including structural differences, expression patterns, alternative splicing, and binding of extracellular and intracellular proteins. This review aims to summarize important aspects of VLDLR and ApoER2 that may account for interesting recent findings that highlight the unique functions of each receptor. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 4% |
Spain | 1 | <1% |
Netherlands | 1 | <1% |
Germany | 1 | <1% |
Unknown | 104 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 25 | 23% |
Student > Master | 21 | 19% |
Student > Bachelor | 18 | 16% |
Researcher | 13 | 12% |
Student > Doctoral Student | 8 | 7% |
Other | 17 | 15% |
Unknown | 9 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 37 | 33% |
Medicine and Dentistry | 20 | 18% |
Biochemistry, Genetics and Molecular Biology | 16 | 14% |
Neuroscience | 15 | 14% |
Chemistry | 3 | 3% |
Other | 9 | 8% |
Unknown | 11 | 10% |