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Mendeley readers
Attention Score in Context
| Title |
Cyclin A2 Mutagenesis Analysis: A New Insight into CDK Activation and Cellular Localization Requirements
|
|---|---|
| Published in |
PLOS ONE, July 2011
|
| DOI | 10.1371/journal.pone.0022879 |
| Pubmed ID | |
| Authors |
Nawal Bendris, Bénédicte Lemmers, Jean-Marie Blanchard, Nikola Arsic |
| Abstract |
Cyclin A2 is essential at two critical points in the somatic cell cycle: during S phase, when it activates CDK2, and during the G2 to M transition when it activates CDK1. Based on the crystal structure of Cyclin A2 in association with CDKs, we generated a panel of mutants to characterize the specific amino acids required for partner binding, CDK activation and subcellular localization. We find that CDK1, CDK2, p21, p27 and p107 have overlapping but distinct requirements for association with this protein. Our data highlight the crucial importance of the N-terminal α helix, in conjunction with the α3 helix within the cyclin box, in activating CDK. Several Cyclin A2 mutants selectively bind to either CDK1 or CDK2. We demonstrate that association of Cyclin A2 to proteins such as CDK2 that was previously suggested as crucial is not a prerequisite for its nuclear localization, and we propose that the whole protein structure is involved. |
Mendeley readers
The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 72 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 19% |
| Student > Master | 9 | 13% |
| Student > Bachelor | 9 | 13% |
| Researcher | 7 | 10% |
| Student > Postgraduate | 6 | 8% |
| Other | 12 | 17% |
| Unknown | 15 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 25% |
| Biochemistry, Genetics and Molecular Biology | 18 | 25% |
| Medicine and Dentistry | 10 | 14% |
| Chemistry | 3 | 4% |
| Unspecified | 2 | 3% |
| Other | 6 | 8% |
| Unknown | 15 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 December 2019.
All research outputs
#7,453,479
of 22,786,691 outputs
Outputs from PLOS ONE
#88,758
of 194,517 outputs
Outputs of similar age
#42,191
of 119,710 outputs
Outputs of similar age from PLOS ONE
#964
of 2,281 outputs
Altmetric has tracked 22,786,691 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 194,517 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 119,710 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2,281 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.