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MicroRNA meta-signature of oral cancer: evidence from a meta-analysis

Overview of attention for article published in Upsala Journal of Medical Sciences, February 2018
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Title
MicroRNA meta-signature of oral cancer: evidence from a meta-analysis
Published in
Upsala Journal of Medical Sciences, February 2018
DOI 10.1080/03009734.2018.1439551
Pubmed ID
Authors

Katarina Zeljic, Ivan Jovanovic, Jasmina Jovanovic, Zvonko Magic, Aleksandra Stankovic, Gordana Supic

Abstract

It was the aim of the study to identify commonly deregulated miRNAs in oral cancer patients by performing a meta-analysis of previously published miRNA expression profiles in cancer and matched normal non-cancerous tissue in such patients. Meta-analysis included seven independent studies analyzed by a vote-counting method followed by bioinformatic enrichment analysis. Amongst seven independent studies included in the meta-analysis, 20 miRNAs were found to be deregulated in oral cancer when compared with non-cancerous tissue. Eleven miRNAs were consistently up-regulated in three or more studies (miR-21-5p, miR-31-5p, miR-135b-5p, miR-31-3p, miR-93-5p, miR-34b-5p, miR-424-5p, miR-18a-5p, miR-455-3p, miR-450a-5p, miR-21-3p), and nine were down-regulated (miR-139-5p, miR-30a-3p, miR-376c-3p, miR-885-5p, miR-375, miR-486-5p, miR-411-5p, miR-133a-3p, miR-30a-5p). The meta-signature of identified miRNAs was functionally characterized by KEGG enrichment analysis. Twenty-four KEGG pathways were significantly enriched, and TGF-beta signaling was the most enriched signaling pathway. The highest number of meta-signature miRNAs was involved in the sphingolipid signaling pathway. Natural killer cell-mediated cytotoxicity was the pathway with most genes regulated by identified miRNAs. The rest of the enriched pathways in our miRNA list describe different malignancies and signaling. The identified miRNA meta-signature might be considered as a potential battery of biomarkers when distinguishing oral cancer tissue from normal, non-cancerous tissue. Further mechanistic studies are warranted in order to confirm and fully elucidate the role of deregulated miRNAs in oral cancer.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 46 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 20%
Student > Ph. D. Student 6 13%
Student > Master 5 11%
Student > Doctoral Student 5 11%
Student > Bachelor 3 7%
Other 10 22%
Unknown 8 17%
Readers by discipline Count As %
Medicine and Dentistry 11 24%
Biochemistry, Genetics and Molecular Biology 10 22%
Agricultural and Biological Sciences 5 11%
Immunology and Microbiology 3 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 4 9%
Unknown 12 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2018.
All research outputs
#10,955,589
of 13,789,144 outputs
Outputs from Upsala Journal of Medical Sciences
#184
of 239 outputs
Outputs of similar age
#203,408
of 271,543 outputs
Outputs of similar age from Upsala Journal of Medical Sciences
#5
of 6 outputs
Altmetric has tracked 13,789,144 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 239 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
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We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.