Title |
A comparison of the psychotropic profiles of tofisopam and diazepam
|
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Published in |
European Journal of Clinical Pharmacology, March 1982
|
DOI | 10.1007/bf00542458 |
Pubmed ID | |
Authors |
A. Bond, M. Lader |
Abstract |
Twelve normal subjects were tested on a number of measures both before and 1,3 and 5 h after 10 mg diazepam, 100 and 200 mg tofisopam and a placebo. The measures included self-ratings of mood, bodily symptoms, hostility and sleep, the electroencephalogram (EEG), reaction time, tapping, digit symbol substitution, the symbol copying test, and plasma levels. Diazepam showed a clear profile of action, producing EEG changes, pronounced sedation and psychological impairment. The last two effects were maximal at 1 h and had worn off by 5 h. The EEG was recorded at 3 h only. Tofisopam in no way resembled diazepam. It produced no changes on the EEG or psychological tests and a very mild stimulant effect was apparent on the ratings. While diazepam was easily detectable in the blood, tofisopam did not bind to benzodiazepine receptors. |
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Geographical breakdown
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Demographic breakdown
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Researcher | 3 | 16% |
Other | 2 | 11% |
Student > Ph. D. Student | 1 | 5% |
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Other | 0 | 0% |
Unknown | 8 | 42% |
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Other | 1 | 5% |
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