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Cellular and behavioral effects of lipopolysaccharide treatment are dependent upon neurokinin-1 receptor activation

Overview of attention for article published in Journal of Neuroinflammation, February 2018
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Title
Cellular and behavioral effects of lipopolysaccharide treatment are dependent upon neurokinin-1 receptor activation
Published in
Journal of Neuroinflammation, February 2018
DOI 10.1186/s12974-018-1098-4
Pubmed ID
Authors

Hannah D. Fulenwider, Britessia M. Smith, Anna S. Nichenko, Jessica M. Carpenter, Sadie E. Nennig, Kejun Cheng, Kenner C. Rice, Jesse R. Schank

Abstract

Several psychiatric conditions are affected by neuroinflammation and neuroimmune activation. The transcription factor nuclear factor kappa light-chain-enhancer of activated B cells (NFkB) plays a major role in inflammation and innate immunity. The neurokinin-1 receptor (NK1R) is the primary endogenous target of the neuroactive peptide substance P, and some data suggests that NK1R stimulation may influence NFkB activity. Both NK1R and NFkB have been shown to play a functional role in complex behaviors including stress responsivity, depression, and addiction. In this study, we test whether NFkB activity in the brain (stimulated by lipopolysaccharide administration) is dependent upon the NK1R. Adult male Wistar rats were treated systemically with the NK1R antagonist L822429 followed by administration of systemic lipopolysaccharide (LPS, a strong activator of NFkB). Hippocampal extracts were used to assess expression of proinflammatory cytokines and NFkB-DNA-binding potential. For behavioral studies, rats were trained to consume 1% (w/v) sucrose solution in a continuous access two-bottle choice model. After establishment of baseline, animals were treated with L822429 and LPS and sucrose preference was measured 12 h post-treatment. Systemic LPS treatment causes a significant increase in proinflammatory cytokine expression and NFkB-DNA-binding activity within the hippocampus. These increases are attenuated by systemic pretreatment with the NK1R antagonist L822429. Systemic LPS treatment also led to the development of anhedonic-like behavior, evidenced by decreased sucrose intake in the sucrose preference test. This behavior was significantly attenuated by systemic pretreatment with the NK1R antagonist L822429. Systemic LPS treatment induced significant increases in NFkB activity, evidenced by increased NFkB-DNA binding and by increased proinflammatory cytokine expression in the hippocampus. LPS also induced anhedonic-like behavior. Both the molecular and behavioral effects of LPS treatment were significantly attenuated by systemic NK1R antagonism, suggesting that NK1R stimulation lies upstream of NFkB activation following systemic LPS administration and is at least in part responsible for NFkB activation.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 24%
Student > Bachelor 4 14%
Researcher 4 14%
Student > Ph. D. Student 3 10%
Unspecified 2 7%
Other 0 0%
Unknown 9 31%
Readers by discipline Count As %
Medicine and Dentistry 4 14%
Biochemistry, Genetics and Molecular Biology 3 10%
Neuroscience 3 10%
Unspecified 2 7%
Psychology 2 7%
Other 6 21%
Unknown 9 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 April 2019.
All research outputs
#11,574,577
of 14,608,133 outputs
Outputs from Journal of Neuroinflammation
#1,273
of 1,747 outputs
Outputs of similar age
#205,365
of 274,441 outputs
Outputs of similar age from Journal of Neuroinflammation
#1
of 1 outputs
Altmetric has tracked 14,608,133 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,747 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
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