Title |
Symptom severity and its effect on health-related quality of life over time in patients with pulmonary hypertension: a multisite longitudinal cohort study
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Published in |
BMJ Open Respiratory Research, March 2018
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DOI | 10.1136/bmjresp-2017-000263 |
Pubmed ID | |
Authors |
Janelle Yorke, Christi Deaton, Malcolm Campbell, Linda McGowen, Paul Sephton, David G Kiely, Iain Armstrong |
Abstract |
The aim of this cohort study was to examine health-related quality of life (HRQoL) and symptomatology in patients with pulmonary hypertension (PH) and explore factors that influence its evolution over time. A prospective longitudinal multisite cohort study. Participants were recruited from specialist UK PH centres and completed a questionnaire pack at baseline, 6, 12 and 18 months to assess HRQoL (emPHasis-10), dyspnoea, fatigue, sleep, anxiety and depression. 185 patients entered the study at baseline and 126 (68%) completed month 18. At baseline, patients had significant impairment of HRQoL, anxiety, depression, dyspnoea and severe fatigue. No significant changes, apart from a reduction in the Hospital Anxiety and Depression Scale-Anxiety score (P=0.04), were observed over 18 months. Depression and dyspnoea were predictors of HRQoL (P=0.002 and P=0.03, respectively). Oxygen use was also associated with diminished HRQoL and increased symptom severity. Patients with PH experience high levels of symptom severity and the negative impact on HRQoL was unchanged over time. The use of oxygen therapy, in particular, was associated with a significant impact on HRQoL. Further study of factors impacting HRQoL and interventions that target a combination of physiological and psychosocial consequences of living with PH are needed. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 20% |
Hong Kong | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 2 | 40% |
Members of the public | 1 | 20% |
Scientists | 1 | 20% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 50 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Postgraduate | 7 | 14% |
Student > Master | 5 | 10% |
Researcher | 5 | 10% |
Student > Bachelor | 4 | 8% |
Student > Ph. D. Student | 3 | 6% |
Other | 8 | 16% |
Unknown | 18 | 36% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 34% |
Nursing and Health Professions | 6 | 12% |
Agricultural and Biological Sciences | 1 | 2% |
Economics, Econometrics and Finance | 1 | 2% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 4 | 8% |
Unknown | 20 | 40% |