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BGLAP is expressed in pancreatic cancer cells and increases their growth and invasion

Overview of attention for article published in Molecular Cancer, January 2007
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Title
BGLAP is expressed in pancreatic cancer cells and increases their growth and invasion
Published in
Molecular Cancer, January 2007
DOI 10.1186/1476-4598-6-83
Pubmed ID
Authors

Hany Kayed, Sandor Bekasi, Shereen Keleg, Christoph W Michalski, Thomas Giese, Helmut Friess, Jörg Kleeff

Abstract

Bone gamma-carboxyglutamate protein (BGLAP; osteocalcin) is a small, highly conserved molecule first identified in the mineralized matrix of bone. It has been implicated in the pathophysiology of various malignancies. In this study, we analyzed the expression and role of BGLAP in the normal human pancreas, chronic pancreatitis (CP), and pancreatic ductal adenocarcinoma (PDAC) using quantitative RT-PCR, immunohistochemistry, immunocytochemistry and enzyme immunoassays, as well as cell proliferation and invasion assays. Gene silencing was carried out using specific siRNA molecules.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 18%
Unknown 9 82%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 45%
Student > Bachelor 2 18%
Other 1 9%
Professor 1 9%
Student > Doctoral Student 1 9%
Other 1 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 36%
Engineering 2 18%
Medicine and Dentistry 2 18%
Chemistry 1 9%
Biochemistry, Genetics and Molecular Biology 1 9%
Other 0 0%
Unknown 1 9%