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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Pib2 and the EGO complex are both required for activation of TORC1
|
|---|---|
| Published in |
Journal of Cell Science, January 2017
|
| DOI | 10.1242/jcs.207910 |
| Pubmed ID | |
| Authors |
Natalia V. Varlakhanova, Michael J. Mihalevic, Kara A. Bernstein, Marijn G. J. Ford |
| Abstract |
The TORC1 complex is a key regulator of cell growth and metabolism in Saccharomyces cerevisiae The vacuole-associated EGO Complex couples activation of TORC1 to the availability of amino acids, specifically glutamine and leucine. EGO Complex is also essential for reactivation of TORC1 following rapamycin-induced growth arrest and for its distribution on the vacuolar membrane. Pib2, a FYVE-containing PI3P-binding protein, is a newly-discovered and poorly characterized activator of TORC1. Here, we show that Pib2 is required for reactivation of TORC1 following rapamycin-induced growth arrest. Pib2 is required for EGO Complex-mediated activation of TORC1 by glutamine and leucine as well as for redistribution of Tor1 on the vacuolar membrane. Therefore, Pib2 and the EGO Complex cooperate to activate TORC1 and connect PI3K signaling and TORC1 activity. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 60 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 28% |
| Researcher | 9 | 15% |
| Student > Bachelor | 7 | 12% |
| Student > Master | 7 | 12% |
| Student > Doctoral Student | 2 | 3% |
| Other | 3 | 5% |
| Unknown | 15 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 22 | 37% |
| Agricultural and Biological Sciences | 15 | 25% |
| Physics and Astronomy | 2 | 3% |
| Social Sciences | 1 | 2% |
| Neuroscience | 1 | 2% |
| Other | 2 | 3% |
| Unknown | 17 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 March 2021.
All research outputs
#7,208,166
of 25,382,440 outputs
Outputs from Journal of Cell Science
#2,976
of 9,021 outputs
Outputs of similar age
#123,330
of 421,709 outputs
Outputs of similar age from Journal of Cell Science
#99
of 311 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 9,021 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,709 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 311 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.