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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Genome‐wide screen identifies a novel p97/CDC‐48‐dependent pathway regulating ER‐stress‐induced gene transcription
|
|---|---|
| Published in |
EMBO Reports, February 2015
|
| DOI | 10.15252/embr.201439123 |
| Pubmed ID | |
| Authors |
Esther Marza, Saïd Taouji, Kim Barroso, Anne-Aurélie Raymond, Léo Guignard, Marc Bonneu, Néstor Pallares-Lupon, Jean-William Dupuy, Martin E Fernandez-Zapico, Jean Rosenbaum, Francesca Palladino, Denis Dupuy, Eric Chevet |
| Abstract |
The accumulation of misfolded proteins in the endoplasmic reticulum (ER) activates the Unfolded Protein Response (UPR(ER)) to restore ER homeostasis. The AAA(+) ATPase p97/CDC-48 plays key roles in ER stress by promoting both ER protein degradation and transcription of UPR(ER) genes. Although the mechanisms associated with protein degradation are now well established, the molecular events involved in the regulation of gene transcription by p97/CDC-48 remain unclear. Using a reporter-based genome-wide RNAi screen in combination with quantitative proteomic analysis in Caenorhabditis elegans, we have identified RUVB-2, a AAA(+) ATPase, as a novel repressor of a subset of UPR(ER) genes. We show that degradation of RUVB-2 by CDC-48 enhances expression of ER stress response genes through an XBP1-dependent mechanism. The functional interplay between CDC-48 and RUVB-2 in controlling transcription of select UPR(ER) genes appears conserved in human cells. Together, these results describe a novel role for p97/CDC-48, whereby its role in protein degradation is integrated with its role in regulating expression of ER stress response genes. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| France | 1 | 2% |
| Unknown | 53 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 27% |
| Researcher | 11 | 20% |
| Professor | 5 | 9% |
| Student > Bachelor | 5 | 9% |
| Student > Master | 5 | 9% |
| Other | 9 | 16% |
| Unknown | 5 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 19 | 35% |
| Agricultural and Biological Sciences | 18 | 33% |
| Medicine and Dentistry | 6 | 11% |
| Chemistry | 3 | 5% |
| Immunology and Microbiology | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 5 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 July 2023.
All research outputs
#6,967,719
of 23,299,593 outputs
Outputs from EMBO Reports
#2,009
of 3,746 outputs
Outputs of similar age
#95,004
of 354,782 outputs
Outputs of similar age from EMBO Reports
#24
of 45 outputs
Altmetric has tracked 23,299,593 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 3,746 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.0. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 354,782 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.