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Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis

Overview of attention for article published in Nature Communications, February 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

Citations

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82 Mendeley
Title
Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis
Published in
Nature Communications, February 2015
DOI 10.1038/ncomms7046
Pubmed ID
Authors

John Bowes, Ashley Budu-Aggrey, Ulrike Huffmeier, Steffen Uebe, Kathryn Steel, Harry L. Hebert, Chris Wallace, Jonathan Massey, Ian N. Bruce, James Bluett, Marie Feletar, Ann W. Morgan, Helena Marzo-Ortega, Gary Donohoe, Derek W. Morris, Philip Helliwell, Anthony W. Ryan, David Kane, Richard B. Warren, Eleanor Korendowych, Gerd-Marie Alenius, Emiliano Giardina, Jonathan Packham, Ross McManus, Oliver FitzGerald, Neil McHugh, Matthew A. Brown, Pauline Ho, Frank Behrens, Harald Burkhardt, Andre Reis, Anne Barton, Bowes J, Budu-Aggrey A, Huffmeier U, Uebe S, Steel K, Hebert HL, Wallace C, Massey J, Bruce IN, Bluett J, Feletar M, Morgan AW, Marzo-Ortega H, Donohoe G, Morris DW, Helliwell P, Ryan AW, Kane D, Warren RB, Korendowych E, Alenius GM, Giardina E, Packham J, McManus R, FitzGerald O, McHugh N, Brown MA, Ho P, Behrens F, Burkhardt H, Reis A, Barton A

Abstract

Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis and, despite the larger estimated heritability for PsA, the majority of genetic susceptibility loci identified to date are shared with psoriasis. Here, we present results from a case-control association study on 1,962 PsA patients and 8,923 controls using the Immunochip genotyping array. We identify eight loci passing genome-wide significance, secondary independent effects at three loci and a distinct PsA-specific variant at the IL23R locus. We report two novel loci and evidence of a novel PsA-specific association at chromosome 5q31. Imputation of classical HLA alleles, amino acids and SNPs across the MHC region highlights three independent associations to class I genes. Finally, we find an enrichment of associated variants to markers of open chromatin in CD8(+) memory primary T cells. This study identifies key insights into the genetics of PsA that could begin to explain fundamental differences between psoriasis and PsA.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 4%
Australia 1 1%
Ireland 1 1%
Netherlands 1 1%
Unknown 76 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 26 32%
Student > Ph. D. Student 16 20%
Student > Master 12 15%
Student > Bachelor 8 10%
Professor 4 5%
Other 16 20%
Readers by discipline Count As %
Medicine and Dentistry 26 32%
Agricultural and Biological Sciences 19 23%
Biochemistry, Genetics and Molecular Biology 18 22%
Unspecified 6 7%
Immunology and Microbiology 4 5%
Other 9 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 50. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 October 2016.
All research outputs
#253,019
of 11,411,056 outputs
Outputs from Nature Communications
#4,374
of 17,156 outputs
Outputs of similar age
#7,925
of 251,485 outputs
Outputs of similar age from Nature Communications
#127
of 596 outputs
Altmetric has tracked 11,411,056 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,156 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 46.7. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,485 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 596 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.