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Ploidy Variation in Kluyveromyces marxianus Separates Dairy and Non-dairy Isolates

Overview of attention for article published in Frontiers in Genetics, March 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (75th percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

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Title
Ploidy Variation in Kluyveromyces marxianus Separates Dairy and Non-dairy Isolates
Published in
Frontiers in Genetics, March 2018
DOI 10.3389/fgene.2018.00094
Pubmed ID
Authors

Raúl A. Ortiz-Merino, Javier A. Varela, Aisling Y. Coughlan, Hisashi Hoshida, Wendel B. da Silveira, Caroline Wilde, Niels G. A. Kuijpers, Jan-Maarten Geertman, Kenneth H. Wolfe, John P. Morrissey

Abstract

Kluyveromyces marxianus is traditionally associated with fermented dairy products, but can also be isolated from diverse non-dairy environments. Because of thermotolerance, rapid growth and other traits, many different strains are being developed for food and industrial applications but there is, as yet, little understanding of the genetic diversity or population genetics of this species. K. marxianus shows a high level of phenotypic variation but the only phenotype that has been clearly linked to a genetic polymorphism is lactose utilisation, which is controlled by variation in the LAC12 gene. The genomes of several strains have been sequenced in recent years and, in this study, we sequenced a further nine strains from different origins. Analysis of the Single Nucleotide Polymorphisms (SNPs) in 14 strains was carried out to examine genome structure and genetic diversity. SNP diversity in K. marxianus is relatively high, with up to 3% DNA sequence divergence between alleles. It was found that the isolates include haploid, diploid, and triploid strains, as shown by both SNP analysis and flow cytometry. Diploids and triploids contain long genomic tracts showing loss of heterozygosity (LOH). All six isolates from dairy environments were diploid or triploid, whereas 6 out 7 isolates from non-dairy environment were haploid. This also correlated with the presence of functional LAC12 alleles only in dairy haplotypes. The diploids were hybrids between a non-dairy and a dairy haplotype, whereas triploids included three copies of a dairy haplotype.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 91 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 18 20%
Student > Ph. D. Student 17 19%
Student > Bachelor 12 13%
Researcher 10 11%
Professor 5 5%
Other 11 12%
Unknown 18 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 31 34%
Agricultural and Biological Sciences 19 21%
Immunology and Microbiology 6 7%
Engineering 5 5%
Business, Management and Accounting 1 1%
Other 6 7%
Unknown 23 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2020.
All research outputs
#4,140,651
of 23,577,654 outputs
Outputs from Frontiers in Genetics
#1,275
of 12,604 outputs
Outputs of similar age
#80,644
of 333,793 outputs
Outputs of similar age from Frontiers in Genetics
#31
of 140 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,604 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 333,793 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 140 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.