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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia
|
|---|---|
| Published in |
Nature Medicine, March 2018
|
| DOI | 10.1038/nm.4501 |
| Pubmed ID | |
| Authors |
Pankaj Baral, Benjamin D Umans, Lu Li, Antonia Wallrapp, Meghna Bist, Talia Kirschbaum, Yibing Wei, Yan Zhou, Vijay K Kuchroo, Patrick R Burkett, Bryan G Yipp, Stephen D Liberles, Isaac M Chiu |
| Abstract |
Lung-innervating nociceptor sensory neurons detect noxious or harmful stimuli and consequently protect organisms by mediating coughing, pain, and bronchoconstriction. However, the role of sensory neurons in pulmonary host defense is unclear. Here, we found that TRPV1+ nociceptors suppressed protective immunity against lethal Staphylococcus aureus pneumonia. Targeted TRPV1+-neuron ablation increased survival, cytokine induction, and lung bacterial clearance. Nociceptors suppressed the recruitment and surveillance of neutrophils, and altered lung γδ T cell numbers, which are necessary for immunity. Vagal ganglia TRPV1+ afferents mediated immunosuppression through release of the neuropeptide calcitonin gene-related peptide (CGRP). Targeting neuroimmunological signaling may be an effective approach to treat lung infections and bacterial pneumonia. |
X Demographics
The data shown below were collected from the profiles of 68 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 19 | 28% |
| United Kingdom | 4 | 6% |
| France | 3 | 4% |
| Singapore | 2 | 3% |
| Taiwan | 1 | 1% |
| Japan | 1 | 1% |
| Australia | 1 | 1% |
| Mexico | 1 | 1% |
| China | 1 | 1% |
| Other | 6 | 9% |
| Unknown | 29 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 42 | 62% |
| Scientists | 14 | 21% |
| Practitioners (doctors, other healthcare professionals) | 6 | 9% |
| Science communicators (journalists, bloggers, editors) | 6 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 398 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 398 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 87 | 22% |
| Researcher | 72 | 18% |
| Student > Bachelor | 38 | 10% |
| Student > Doctoral Student | 21 | 5% |
| Student > Master | 20 | 5% |
| Other | 55 | 14% |
| Unknown | 105 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 73 | 18% |
| Neuroscience | 50 | 13% |
| Biochemistry, Genetics and Molecular Biology | 48 | 12% |
| Agricultural and Biological Sciences | 48 | 12% |
| Medicine and Dentistry | 39 | 10% |
| Other | 27 | 7% |
| Unknown | 113 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 138. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 April 2024.
All research outputs
#307,985
of 25,884,216 outputs
Outputs from Nature Medicine
#1,153
of 9,469 outputs
Outputs of similar age
#6,967
of 350,091 outputs
Outputs of similar age from Nature Medicine
#19
of 61 outputs
Altmetric has tracked 25,884,216 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,469 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 106.2. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 350,091 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.