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Early life Triclosan exposure and child adiposity at 8 Years of age: a prospective cohort study

Overview of attention for article published in Environmental Health, March 2018
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Title
Early life Triclosan exposure and child adiposity at 8 Years of age: a prospective cohort study
Published in
Environmental Health, March 2018
DOI 10.1186/s12940-018-0366-1
Pubmed ID
Authors

Geetika Kalloo, Antonia M. Calafat, Aimin Chen, Kimberly Yolton, Bruce P. Lanphear, Joseph M. Braun

Abstract

Triclosan is an antimicrobial agent that may affect the gut microbiome and endocrine system to influence adiposity. However, little data from prospective studies examining prenatal and childhood exposures exist. We investigated the relationship between multiple, prospective early life measure of triclosan exposure and child adiposity.  METHODS: In a prospective cohort of 220 mother-child pairs from Cincinnati, OH (enrolled 2003-2006), we quantified triclosan in urine samples collected twice during pregnancy, annually from 1 to 5 years of age, and once at 8 years. We assessed child adiposity at age 8 years using body mass index (BMI), waist circumference, and bioelectric impedance. We estimated covariate-adjusted associations of child adiposity with a 10-fold increase in average prenatal, average early childhood (average of 1-5 years), and 8-year triclosan concentrations. Among all children, there was no association between triclosan and child adiposity. While urinary triclosan concentrations at all three time periods were weakly, imprecisely, and inversely associated with all three measures of adiposity among girls, these associations did not differ significantly from those in boys (sex x triclosan p-values> 0.35). Among girls, the strongest associations were generally observed for prenatal triclosan when we adjusted for all three triclosan concentrations and covariates in the same model; BMI z-score (β: -0.13; 95% CI: -0.42, 0.15), waist circumference (β: - 1.7 cm; 95% CI: -4.2, 0.7), and percent body fat (β :-0.6; 95% CI: -2.7, 1.3). In contrast, the associations between triclosan concentrations and adiposity measures were inconsistent among boys. We did not observe evidence of an association of repeated urinary triclosan concentrations during pregnancy and childhood with measures of child adiposity at age 8 years in this cohort.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 68 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 15%
Researcher 9 13%
Student > Master 8 12%
Student > Bachelor 7 10%
Student > Doctoral Student 4 6%
Other 10 15%
Unknown 20 29%
Readers by discipline Count As %
Environmental Science 9 13%
Medicine and Dentistry 7 10%
Agricultural and Biological Sciences 5 7%
Nursing and Health Professions 4 6%
Psychology 3 4%
Other 12 18%
Unknown 28 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2018.
All research outputs
#17,932,482
of 23,025,074 outputs
Outputs from Environmental Health
#1,220
of 1,506 outputs
Outputs of similar age
#241,402
of 332,016 outputs
Outputs of similar age from Environmental Health
#24
of 31 outputs
Altmetric has tracked 23,025,074 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.