Exhaustion of the CD8+ T Cell Compartment in Patients with Mutations in Phosphoinositide 3-Kinase Delta (PI3Kδ) https://t.co/zIExzQfjIE "PD-1 checkpoint inhibition may provide a possible therapeutic approach to support the immune system of APDS patients
https://t.co/zIExzQfjIE "Because inhibitory receptor upregulation may possibly be beneficial in APDS by preventing excessive inflammation or autoimmunity, manipulating this pathway has to be done with caution, and ideally it should be combined with ... se
https://t.co/zIExzQfjIE "Pathogenic gain-of-function mutations in the gene encoding (PI3Kδ) cause activated PI3Kδ syndrome (APDS), a disease characterized by humoral immunodeficiency, lymphadenopathy, & an inability to control persistent viral infecti
RT @palterer: "Exhaustion of the CD8+ T Cell Compartment in Patients with Mutations in Phosphoinositide 3-Kinase Delta" https://t.co/dGYl3Z…