Title |
Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel™
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Published in |
Investigational New Drugs, January 2005
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DOI | 10.1007/s10637-005-5856-7 |
Pubmed ID | |
Authors |
Ephraim Philip Lansky, Gregory Harrison, Paul Froom, Wen G. Jiang |
Abstract |
Four pure chemicals, ellagic acid (E), caffeic acid (C), luteolin (L) and punicic acid (P), all important components of the aqueous compartments or oily compartment of pomegranate fruit (Punica granatum), and each belonging to different representative chemical classes and showing known anticancer activities, were tested as potential inhibitors of in vitro invasion of human PC-3 prostate cancer cells in an assay employing Matrigel artificial membranes. All compounds significantly inhibited invasion when employed individually. When C, P, and L were equally combined at the same gross dosage (4 microg/ml) as when the compounds were tested individually, a supradditive inhibition of invasion was observed, measured by the Kruskal-Wallis non-parametric test. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Malaysia | 1 | 1% |
India | 1 | 1% |
Unknown | 80 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 15 | 18% |
Student > Ph. D. Student | 10 | 12% |
Researcher | 8 | 10% |
Student > Master | 8 | 10% |
Other | 5 | 6% |
Other | 13 | 16% |
Unknown | 23 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 19 | 23% |
Pharmacology, Toxicology and Pharmaceutical Science | 9 | 11% |
Biochemistry, Genetics and Molecular Biology | 8 | 10% |
Chemistry | 7 | 9% |
Medicine and Dentistry | 5 | 6% |
Other | 8 | 10% |
Unknown | 26 | 32% |