Title |
The CLC chloride channel family
|
---|---|
Published in |
Pflügers Archiv - European Journal of Physiology, April 1999
|
DOI | 10.1007/s004240050847 |
Pubmed ID | |
Authors |
T. J. Jentsch, Thomas Friedrich, Antje Schriever, Hideomi Yamada |
Abstract |
Chloride channels perform important roles in the regulation of cellular excitability, in transepithelial transport, cell volume regulation, and acidification of intracellular organelles. This variety of functions requires a large number of different chloride channels that are encoded by genes belonging to several unrelated gene families. The CLC family of chloride channels has nine known members in mammals that show a differential tissue distribution and function both in plasma membranes and in intracellular organelles. CLC proteins have about 10-12 transmembrane domains. They probably function as dimers and may have two pores. The functional expression of channels altered by site-directed mutagenesis has led to important insights into their structure-function relationship. Their physiological relevance is obvious from three human inherited diseases (myotonia congenita, Dent's disease and Bartter's syndrome) that result from mutations in some of their members and from a knock-out mouse model. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 2% |
United Kingdom | 2 | 2% |
Switzerland | 1 | <1% |
Portugal | 1 | <1% |
Uganda | 1 | <1% |
Unknown | 114 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 31 | 26% |
Researcher | 21 | 17% |
Professor > Associate Professor | 12 | 10% |
Student > Bachelor | 11 | 9% |
Student > Doctoral Student | 9 | 7% |
Other | 25 | 21% |
Unknown | 12 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 46 | 38% |
Medicine and Dentistry | 18 | 15% |
Biochemistry, Genetics and Molecular Biology | 15 | 12% |
Neuroscience | 9 | 7% |
Chemistry | 7 | 6% |
Other | 10 | 8% |
Unknown | 16 | 13% |