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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A systematic approach to the development of a safe live attenuated Zika vaccine
|
|---|---|
| Published in |
Nature Communications, March 2018
|
| DOI | 10.1038/s41467-018-03337-2 |
| Pubmed ID | |
| Authors |
Swee Sen Kwek, Satoru Watanabe, Kuan Rong Chan, Eugenia Z. Ong, Hwee Cheng Tan, Wy Ching Ng, Mien T. X. Nguyen, Esther S. Gan, Summer L. Zhang, Kitti W. K. Chan, Jun Hao Tan, October M. Sessions, Menchie Manuel, Julien Pompon, Camillus Chua, Sharifah Hazirah, Karl Tryggvason, Subhash G. Vasudevan, Eng Eong Ooi |
| Abstract |
Zika virus (ZIKV) is a flavivirus that can cause congenital disease and requires development of an effective long-term preventative strategy. A replicative ZIKV vaccine with properties similar to the yellow fever 17D (YF17D) live-attenuated vaccine (LAV) would be advantageous, as a single dose of YF17D produces lifelong immunity. However, a replicative ZIKV vaccine must also be safe from causing persistent organ infections. Here we report an approach to ZIKV LAV development. We identify a ZIKV variant that produces small plaques due to interferon (IFN)-restricted viral propagation and displays attenuated infection of endothelial cells. We show that these properties collectively reduce the risk of organ infections and vertical transmission in a mouse model but remain sufficiently immunogenic to prevent wild-type ZIKV infection. Our findings suggest a strategy for the development of a safe but efficacious ZIKV LAV. |
X Demographics
The data shown below were collected from the profiles of 22 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Singapore | 3 | 14% |
| United States | 3 | 14% |
| Australia | 1 | 5% |
| Switzerland | 1 | 5% |
| Hong Kong | 1 | 5% |
| Brazil | 1 | 5% |
| Portugal | 1 | 5% |
| Unknown | 11 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 50% |
| Scientists | 9 | 41% |
| Science communicators (journalists, bloggers, editors) | 2 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 90 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 14% |
| Student > Ph. D. Student | 12 | 13% |
| Student > Master | 11 | 12% |
| Student > Bachelor | 9 | 10% |
| Other | 8 | 9% |
| Other | 12 | 13% |
| Unknown | 25 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 18 | 20% |
| Biochemistry, Genetics and Molecular Biology | 10 | 11% |
| Agricultural and Biological Sciences | 9 | 10% |
| Medicine and Dentistry | 7 | 8% |
| Social Sciences | 3 | 3% |
| Other | 13 | 14% |
| Unknown | 30 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 60. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 November 2018.
All research outputs
#632,681
of 23,577,654 outputs
Outputs from Nature Communications
#10,985
of 49,108 outputs
Outputs of similar age
#15,681
of 333,929 outputs
Outputs of similar age from Nature Communications
#337
of 1,224 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 49,108 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.2. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 333,929 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 1,224 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.