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Presence of the CYP2B6 516G> T polymorphism, increased plasma Efavirenz concentrations and early neuropsychiatric side effects in South African HIV-infected patients

Overview of attention for article published in AIDS Research and Therapy, August 2010
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About this Attention Score

  • Among the highest-scoring outputs from this source (#32 of 156)
  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

wikipedia
1 Wikipedia page

Citations

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86 Dimensions

Readers on

mendeley
68 Mendeley
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Title
Presence of the CYP2B6 516G> T polymorphism, increased plasma Efavirenz concentrations and early neuropsychiatric side effects in South African HIV-infected patients
Published in
AIDS Research and Therapy, August 2010
DOI 10.1186/1742-6405-7-32
Pubmed ID
Authors

Verena Gounden, Chantal van Niekerk, Tracy Snyman, Jaya A George

Abstract

The 516G > T polymorphism in exon 4 of the CYP2B6 gene has been associated with increased plasma Efavirenz (EFV) concentrations. EFV concentrations greater than the recommended therapeutic range have been associated with the increased likelihood of developing adverse CNS effects. The aims of this study were to a) determine the presence of the 516G > T and other CYP2B6 exon 4 polymorphisms in a South African group of HIV-infected individuals b) investigate the relationship between the EFV plasma concentrations, the CYP2B6 516G > T polymorphism and the occurrence of CNS related side effects in this group of patients and c) develop and validate a rapid method for determination of EFV in plasma.

Mendeley readers

The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
South Africa 2 3%
Peru 1 1%
Nigeria 1 1%
Unknown 64 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 24%
Student > Master 14 21%
Student > Postgraduate 9 13%
Student > Bachelor 7 10%
Researcher 6 9%
Other 11 16%
Unknown 5 7%
Readers by discipline Count As %
Medicine and Dentistry 24 35%
Agricultural and Biological Sciences 15 22%
Pharmacology, Toxicology and Pharmaceutical Science 9 13%
Biochemistry, Genetics and Molecular Biology 5 7%
Immunology and Microbiology 2 3%
Other 7 10%
Unknown 6 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 January 2011.
All research outputs
#816,479
of 3,629,479 outputs
Outputs from AIDS Research and Therapy
#32
of 156 outputs
Outputs of similar age
#24,302
of 94,062 outputs
Outputs of similar age from AIDS Research and Therapy
#2
of 10 outputs
Altmetric has tracked 3,629,479 research outputs across all sources so far. This one has received more attention than most of these and is in the 63rd percentile.
So far Altmetric has tracked 156 research outputs from this source. They receive a mean Attention Score of 2.0. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,062 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 8 of them.