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Predictive ability of NGAL in identifying urinary tract infection in children with neurogenic bladders

Overview of attention for article published in Pediatric Nephrology, March 2018
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  • Above-average Attention Score compared to outputs of the same age (63rd percentile)
  • Average Attention Score compared to outputs of the same age and source

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Title
Predictive ability of NGAL in identifying urinary tract infection in children with neurogenic bladders
Published in
Pediatric Nephrology, March 2018
DOI 10.1007/s00467-018-3936-0
Pubmed ID
Authors

Catherine S. Forster, Elizabeth Jackson, Qing Ma, Michael Bennett, Samir S. Shah, Stuart L. Goldstein

Abstract

Distinguishing between urinary tract infection (UTI) and colonization (UTC) in patients with neurogenic bladders who require clean intermittent catheterization (CIC) is difficult. Urinary neutrophil gelatinase-associated lipocalin concentrations (uNGAL) are increased in UTIs. Our objective was to determine the predictive accuracy of uNGAL for UTI in CIC-dependent children. Cross-sectional study of CIC-dependent patients from August, 2015 to November, 2016. UTI was defined as (1) growth of ≥ 50,000 cfu/mL of a uropathogen, (2) > 10 urinary white blood cells/hpf, and (3) ≥ 2 of the following: temperature > 38 °C, abdominal pain, back pain, worsened incontinence, pain with catheterization, or malodorous/cloudy urine. Positive urine cultures that did not meet these criteria were grouped as UTC, and negative cultures were grouped as no growth. Two hundred one patients were included (no growth = 100, UTC = 77, UTI = 24). Median (interquartile range) uNGAL was higher in the UTI group (UTI 1361 (931, 2516) μg/g creatinine, UTC 246 (106, 548) μg/g creatinine, no growth 36 (11, 179) μg/g creatinine, p < 0.01 for all comparisons). The area under the ROC curve for uNGAL for UTI versus no UTI was 0.89, 95% CI (0.80-0.98). uNGAL is elevated in CIC-dependent children with UTI compared to those with negative cultures and those with UTC.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 53 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 11 21%
Other 10 19%
Researcher 5 9%
Student > Bachelor 5 9%
Professor 2 4%
Other 8 15%
Unknown 12 23%
Readers by discipline Count As %
Medicine and Dentistry 26 49%
Nursing and Health Professions 2 4%
Computer Science 2 4%
Immunology and Microbiology 2 4%
Business, Management and Accounting 1 2%
Other 4 8%
Unknown 16 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2021.
All research outputs
#6,871,331
of 23,026,672 outputs
Outputs from Pediatric Nephrology
#1,299
of 3,591 outputs
Outputs of similar age
#120,429
of 332,696 outputs
Outputs of similar age from Pediatric Nephrology
#41
of 77 outputs
Altmetric has tracked 23,026,672 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 3,591 research outputs from this source. They receive a mean Attention Score of 4.9. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 332,696 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.