Title |
The subcommissural organ of the rat secretes Reissner's fiber glycoproteins and CSF-soluble proteins reaching the internal and external CSF compartments
|
---|---|
Published in |
Fluids and Barriers of the CNS, January 2008
|
DOI | 10.1186/1743-8454-5-3 |
Pubmed ID | |
Authors |
Karin Vio, Sara Rodríguez, Carlos R Yulis, Cristian Oliver, Esteban M Rodríguez |
Abstract |
The subcommissural organ (SCO) is a highly conserved brain gland present throughout the vertebrate phylum; it secretes glycoproteins into the cerebrospinal fluid (CSF), where they aggregate to form Reissner's fiber (RF). SCO-spondin is the major constituent protein of RF. Evidence exists that the SCO also secretes proteins that remain soluble in the CSF. The aims of the present investigation were: (i) to identify and partially characterize the SCO-secretory compounds present in the SCO gland itself and in the RF of the Sprague-Dawley rat and non-hydrocephalic hyh mouse, and in the CSF of rat; (ii) to make a comparative analysis of the proteins present in these three compartments; (iii) to identify the proteins secreted by the SCO into the CSF at different developmental periods. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 48 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 21% |
Researcher | 9 | 19% |
Student > Bachelor | 4 | 8% |
Student > Postgraduate | 4 | 8% |
Student > Master | 3 | 6% |
Other | 9 | 19% |
Unknown | 9 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 18 | 38% |
Neuroscience | 7 | 15% |
Biochemistry, Genetics and Molecular Biology | 6 | 13% |
Medicine and Dentistry | 5 | 10% |
Chemistry | 1 | 2% |
Other | 0 | 0% |
Unknown | 11 | 23% |