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Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis.

Overview of attention for article published in Critical Care, February 2012
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Mentioned by

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1 tweeter

Citations

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40 Dimensions

Readers on

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54 Mendeley
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Title
Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis.
Published in
Critical Care, February 2012
DOI 10.1186/1364-8535-16-r32
Pubmed ID
Authors

Bitto A, Minutoli L, David A, Irrera N, Rinaldi M, Venuti FS, Squadrito F, Altavilla D

Abstract

Cecal ligation and puncture (CLP) is an inflammatory condition that leads to multisystemic organ failure. Flavocoxid, a dual inhibitor of cyclooxygenase (COX-2) and 5-lipoxygenase (5-LOX), has been shown in vitro to possess antiinflammatory activity in lipopolysaccharide (LPS)-stimulated rat macrophages by reducing nuclear factor (NF)-κB activity and COX-2, 5-LOX and inducible nitric oxide synthase (iNOS) expression. The aim of this study was to evaluate the effects of flavocoxid in a murine model of CLP-induced polymicrobial sepsis.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 2%
Brazil 1 2%
India 1 2%
Denmark 1 2%
Romania 1 2%
Unknown 49 91%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 24%
Researcher 11 20%
Student > Ph. D. Student 11 20%
Student > Postgraduate 6 11%
Student > Doctoral Student 4 7%
Other 7 13%
Unknown 2 4%
Readers by discipline Count As %
Medicine and Dentistry 20 37%
Agricultural and Biological Sciences 12 22%
Biochemistry, Genetics and Molecular Biology 8 15%
Chemistry 3 6%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Other 5 9%
Unknown 4 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 February 2015.
All research outputs
#3,956,495
of 4,724,476 outputs
Outputs from Critical Care
#2,474
of 2,608 outputs
Outputs of similar age
#133,178
of 165,267 outputs
Outputs of similar age from Critical Care
#153
of 158 outputs
Altmetric has tracked 4,724,476 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,608 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 165,267 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 158 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.