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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Copper-Catalyzed Chan–Lam Cyclopropylation of Phenols and Azaheterocycles
|
|---|---|
| Published in |
Journal of Organic Chemistry, March 2018
|
| DOI | 10.1021/acs.joc.7b03100 |
| Pubmed ID | |
| Authors |
Joseph Derosa, Miriam L. O’Duill, Matthew Holcomb, Mark N. Boulous, Ryan L. Patman, Fen Wang, Michelle Tran-Dubé, Indrawan McAlpine, Keary M. Engle |
| Abstract |
Small molecules containing cyclopropane-heteroatom linkages are commonly needed in medicinal chemistry campaigns, yet are problematic to prepare using existing methods. To address this issue, a scalable Chan-Lam cyclopropylation reaction using potassium cyclopropyl trifluoroborate has been developed. With phenol nucleophiles, the reaction effects O-cyclopropylation, whereas with 2-pyridones, 2-hydroxybenzimidazoles, and 2-aminopyridines the reaction brings about N-cyclopropylation. The transformation is catalyzed by Cu(OAc)2 and 1,10-phenanthroline and employs 1 atm O2 as the terminal oxidant. This method is operationally convenient to perform and provides a simple, strategic disconnection toward the synthesis of cyclopropyl aryl ethers and cyclopropyl amine derivatives bearing an array of functional groups. |
X Demographics
The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 40% |
| Luxembourg | 1 | 7% |
| Japan | 1 | 7% |
| Mexico | 1 | 7% |
| Brazil | 1 | 7% |
| India | 1 | 7% |
| Unknown | 4 | 27% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 47% |
| Scientists | 7 | 47% |
| Science communicators (journalists, bloggers, editors) | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 59 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 11 | 19% |
| Researcher | 11 | 19% |
| Student > Ph. D. Student | 9 | 15% |
| Student > Doctoral Student | 3 | 5% |
| Other | 3 | 5% |
| Other | 11 | 19% |
| Unknown | 11 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 44 | 75% |
| Biochemistry, Genetics and Molecular Biology | 3 | 5% |
| Chemical Engineering | 1 | 2% |
| Medicine and Dentistry | 1 | 2% |
| Unknown | 10 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2018.
All research outputs
#4,590,757
of 25,382,440 outputs
Outputs from Journal of Organic Chemistry
#3,544
of 28,618 outputs
Outputs of similar age
#84,053
of 346,135 outputs
Outputs of similar age from Journal of Organic Chemistry
#25
of 201 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 28,618 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 346,135 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 201 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.