↓ Skip to main content

Coordinate and redox interactions of epinephrine with ferric and ferrous iron at physiological pH

Overview of attention for article published in Scientific Reports, February 2018
Altmetric Badge

About this Attention Score

  • Average Attention Score compared to outputs of the same age

Mentioned by

twitter
1 tweeter

Citations

dimensions_citation
7 Dimensions

Readers on

mendeley
20 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Coordinate and redox interactions of epinephrine with ferric and ferrous iron at physiological pH
Published in
Scientific Reports, February 2018
DOI 10.1038/s41598-018-21940-7
Pubmed ID
Authors

Jelena Korać, Dalibor M. Stanković, Marina Stanić, Danica Bajuk-Bogdanović, Milan Žižić, Jelena Bogdanović Pristov, Sanja Grgurić-Šipka, Ana Popović-Bijelić, Ivan Spasojević

Abstract

Coordinate and redox interactions of epinephrine (Epi) with iron at physiological pH are essential for understanding two very different phenomena - the detrimental effects of chronic stress on the cardiovascular system and the cross-linking of catecholamine-rich biopolymers and frameworks. Here we show that Epi and Fe3+form stable high-spin complexes in the 1:1 or 3:1 stoichiometry, depending on the Epi/Fe3+concentration ratio (low or high). Oxygen atoms on the catechol ring represent the sites of coordinate bond formation within physiologically relevant bidentate 1:1 complex. Redox properties of Epi are slightly impacted by Fe3+. On the other hand, Epi and Fe2+form a complex that acts as a strong reducing agent, which leads to the production of hydrogen peroxide via O2reduction, and to a facilitated formation of the Epi-Fe3+complexes. Epi is not oxidized in this process, i.e. Fe2+is not an electron shuttle, but the electron donor. Epi-catalyzed oxidation of Fe2+represents a plausible chemical basis of stress-related damage to heart cells. In addition, our results support the previous findings on the interactions of catecholamine moieties in polymers with iron and provide a novel strategy for improving the efficiency of cross-linking.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 20%
Other 3 15%
Researcher 2 10%
Student > Bachelor 2 10%
Professor 1 5%
Other 4 20%
Unknown 4 20%
Readers by discipline Count As %
Chemistry 6 30%
Agricultural and Biological Sciences 4 20%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Chemical Engineering 1 5%
Arts and Humanities 1 5%
Other 0 0%
Unknown 7 35%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2020.
All research outputs
#11,232,135
of 17,353,889 outputs
Outputs from Scientific Reports
#56,368
of 93,291 outputs
Outputs of similar age
#173,738
of 285,989 outputs
Outputs of similar age from Scientific Reports
#1
of 4 outputs
Altmetric has tracked 17,353,889 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 93,291 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.7. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 285,989 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them