Title |
Evolving concepts in advanced glycation, diabetic nephropathy, and diabetic vascular disease
|
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Published in |
Molecular Cell Biology Research Communications, November 2003
|
DOI | 10.1016/j.abb.2003.08.017 |
Pubmed ID | |
Authors |
George Jerums, Sianna Panagiotopoulos, Josephine Forbes, Tanya Osicka, Mark Cooper |
Abstract |
Advanced glycation endproducts (AGEs) have been postulated to play a role in the development of both nephropathy and large vessel disease in diabetes. However, it is still not clear which AGE subtypes play a pathogenetic role and which of several AGE receptors mediate AGE effects on cells. This review summarises the renoprotective effect of inhibitors of AGE formation, including aminoguanidine, and of cross-link breakers, including ALT-711, on experimental diabetic nephropathy and on mesenteric vascular hypertrophy. It also demonstrates similar effects of aminoguanidine and ramipril (an angiotensin converting enzyme inhibitor) on fluorescent and immunoassayable AGE levels, renal protein kinase C activity, nitrotyrosine expression, lysosomal function, and protein handling in experimental diabetes. These findings indicate that inhibition of the renin angiotensin system blocks both upstream and downstream pathways leading to tissue injury. We postulate that the chemical pathways leading to advanced glycation endproduct formation and the renin angiotensin systems may interact through the generation of free radicals, induced both by glucose and angiotensin II. There is also evidence to suggest that AGE-dependent pathways may play a role in the development of tubulointerstitial fibrosis in the diabetic kidney. This effect is mediated through RAGE and is TGF-beta and CTGF-dependent. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 7% |
Unknown | 26 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 18% |
Student > Ph. D. Student | 4 | 14% |
Student > Master | 4 | 14% |
Professor > Associate Professor | 3 | 11% |
Professor | 3 | 11% |
Other | 6 | 21% |
Unknown | 3 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 10 | 36% |
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Medicine and Dentistry | 4 | 14% |
Chemistry | 2 | 7% |
Nursing and Health Professions | 1 | 4% |
Other | 4 | 14% |
Unknown | 2 | 7% |