Title |
Dietary carbohydrates impair the protective effect of protein restriction against diabetes in NZO mice used as a model of type 2 diabetes
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Published in |
Diabetologia, March 2018
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DOI | 10.1007/s00125-018-4595-1 |
Pubmed ID | |
Authors |
Thomas Laeger, Teresa Castaño-Martinez, Martin W. Werno, Lukasz Japtok, Christian Baumeier, Wenke Jonas, Burkhard Kleuser, Annette Schürmann |
Abstract |
Low-protein diets are well known to improve glucose tolerance and increase energy expenditure. Increases in circulating fibroblast growth factor 21 (FGF21) have been implicated as a potential underlying mechanism. We aimed to test whether low-protein diets in the context of a high-carbohydrate or high-fat regimen would also protect against type 2 diabetes in New Zealand Obese (NZO) mice used as a model of polygenetic obesity and type 2 diabetes. Mice were placed on high-fat diets that provided protein at control (16 kJ%; CON) or low (4 kJ%; low-protein/high-carbohydrate [LP/HC] or low-protein/high-fat [LP/HF]) levels. Protein restriction prevented the onset of hyperglycaemia and beta cell loss despite increased food intake and fat mass. The effect was seen only under conditions of a lower carbohydrate/fat ratio (LP/HF). When the carbohydrate/fat ratio was high (LP/HC), mice developed type 2 diabetes despite the robustly elevated hepatic FGF21 secretion and increased energy expenditure. Prevention of type 2 diabetes through protein restriction, without lowering food intake and body fat mass, is compromised by high dietary carbohydrates. Increased FGF21 levels and elevated energy expenditure do not protect against hyperglycaemia and type 2 diabetes per se. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 14% |
United Kingdom | 1 | 14% |
United States | 1 | 14% |
Unknown | 4 | 57% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 57% |
Practitioners (doctors, other healthcare professionals) | 2 | 29% |
Scientists | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 39 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 18% |
Student > Master | 5 | 13% |
Researcher | 5 | 13% |
Student > Doctoral Student | 2 | 5% |
Lecturer | 1 | 3% |
Other | 4 | 10% |
Unknown | 15 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 8 | 21% |
Biochemistry, Genetics and Molecular Biology | 4 | 10% |
Sports and Recreations | 3 | 8% |
Medicine and Dentistry | 3 | 8% |
Nursing and Health Professions | 2 | 5% |
Other | 3 | 8% |
Unknown | 16 | 41% |