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TNF-α Mediates Eosinophil Cationic Protein-induced Apoptosis in BEAS-2B Cells

Overview of attention for article published in BMC Molecular and Cell Biology, January 2010
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Mentioned by

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2 Wikipedia pages

Citations

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34 Dimensions

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37 Mendeley
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Title
TNF-α Mediates Eosinophil Cationic Protein-induced Apoptosis in BEAS-2B Cells
Published in
BMC Molecular and Cell Biology, January 2010
DOI 10.1186/1471-2121-11-6
Pubmed ID
Authors

Kun-Che Chang, Chih-Wei Lo, Tan-chi Fan, Margaret Dah-Tsyr Chang, Chih-Wen Shu, Chuan-Hsin Chang, Cheng-Ta Chung, Shun-lung Fang, Chih-Chung Chao, Jaw-Ji Tsai, Yiu-Kay Lai

Abstract

Eosinophilic granulocytes are important for the human immune system. Many cationic proteins with cytotoxic activities, such as eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin (EDN), are released from activated eosinophils. ECP, with low RNase activity, is widely used as a biomarker for asthma. ECP inhibits cell viability and induces apoptosis to cells. However, the specific pathway underlying the mechanisms of ECP-induced cytotoxicity remains unclear. This study investigated ECP-induced apoptosis in bronchial epithelial BEAS-2B cells and elucidated the specific pathway during apoptosis.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 5%
Canada 1 3%
Unknown 34 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 27%
Professor > Associate Professor 5 14%
Professor 4 11%
Researcher 4 11%
Student > Doctoral Student 3 8%
Other 5 14%
Unknown 6 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 35%
Biochemistry, Genetics and Molecular Biology 6 16%
Medicine and Dentistry 6 16%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Chemistry 2 5%
Other 0 0%
Unknown 8 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2016.
All research outputs
#8,535,684
of 25,374,917 outputs
Outputs from BMC Molecular and Cell Biology
#334
of 1,233 outputs
Outputs of similar age
#51,069
of 172,231 outputs
Outputs of similar age from BMC Molecular and Cell Biology
#7
of 13 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,233 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,231 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.