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TNF-α Mediates Eosinophil Cationic Protein-induced Apoptosis in BEAS-2B Cells

Overview of attention for article published in BMC Cell Biology, January 2010
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About this Attention Score

  • Among the highest-scoring outputs from this source (#19 of 152)
  • Good Attention Score compared to outputs of the same age (72nd percentile)

Mentioned by

wikipedia
1 Wikipedia page

Citations

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28 Dimensions

Readers on

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30 Mendeley
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Title
TNF-α Mediates Eosinophil Cationic Protein-induced Apoptosis in BEAS-2B Cells
Published in
BMC Cell Biology, January 2010
DOI 10.1186/1471-2121-11-6
Pubmed ID
Authors

Kun-Che Chang, Chih-Wei Lo, Tan-chi Fan, Margaret Chang, Chih-Wen Shu, Chuan-Hsin Chang, Cheng-Ta Chung, Shun-lung Fang, Chih-Chung Chao, Jaw-Ji Tsai, Yiu-Kay Lai

Abstract

Eosinophilic granulocytes are important for the human immune system. Many cationic proteins with cytotoxic activities, such as eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin (EDN), are released from activated eosinophils. ECP, with low RNase activity, is widely used as a biomarker for asthma. ECP inhibits cell viability and induces apoptosis to cells. However, the specific pathway underlying the mechanisms of ECP-induced cytotoxicity remains unclear. This study investigated ECP-induced apoptosis in bronchial epithelial BEAS-2B cells and elucidated the specific pathway during apoptosis.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 7%
Canada 1 3%
Unknown 27 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 30%
Professor > Associate Professor 5 17%
Researcher 4 13%
Professor 3 10%
Student > Postgraduate 3 10%
Other 6 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 43%
Medicine and Dentistry 6 20%
Biochemistry, Genetics and Molecular Biology 5 17%
Unspecified 3 10%
Chemistry 2 7%
Other 1 3%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 May 2010.
All research outputs
#816,097
of 3,631,265 outputs
Outputs from BMC Cell Biology
#19
of 152 outputs
Outputs of similar age
#24,949
of 95,769 outputs
Outputs of similar age from BMC Cell Biology
#1
of 4 outputs
Altmetric has tracked 3,631,265 research outputs across all sources so far. This one has received more attention than most of these and is in the 63rd percentile.
So far Altmetric has tracked 152 research outputs from this source. They receive a mean Attention Score of 1.8. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 95,769 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them