Title |
TNF-α Mediates Eosinophil Cationic Protein-induced Apoptosis in BEAS-2B Cells
|
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Published in |
BMC Molecular and Cell Biology, January 2010
|
DOI | 10.1186/1471-2121-11-6 |
Pubmed ID | |
Authors |
Kun-Che Chang, Chih-Wei Lo, Tan-chi Fan, Margaret Dah-Tsyr Chang, Chih-Wen Shu, Chuan-Hsin Chang, Cheng-Ta Chung, Shun-lung Fang, Chih-Chung Chao, Jaw-Ji Tsai, Yiu-Kay Lai |
Abstract |
Eosinophilic granulocytes are important for the human immune system. Many cationic proteins with cytotoxic activities, such as eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin (EDN), are released from activated eosinophils. ECP, with low RNase activity, is widely used as a biomarker for asthma. ECP inhibits cell viability and induces apoptosis to cells. However, the specific pathway underlying the mechanisms of ECP-induced cytotoxicity remains unclear. This study investigated ECP-induced apoptosis in bronchial epithelial BEAS-2B cells and elucidated the specific pathway during apoptosis. |
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Demographic breakdown
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Other | 0 | 0% |
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