Title |
Microtubules and axon regeneration in C. elegans
|
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Published in |
MCN: Molecular & Cellular Neuroscience, March 2018
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DOI | 10.1016/j.mcn.2018.03.007 |
Pubmed ID | |
Authors |
Lizhen Chen |
Abstract |
Axon regeneration is a fundamental and conserved process that allows the nervous system to repair circuits after trauma. Due to its conserved genome, transparent body, and relatively simple neuroanatomy, C. elegans has become a powerful model organism for studying the cellular and molecular mechanisms underlying axon regeneration. Various studies from different model organisms have found microtubule dynamics to be pivotal to axon regrowth. In this review, we will discuss the latest findings on how microtubule dynamics are regulated during axon regeneration in C. elegans. Understanding the mechanisms of axon regeneration will aid in the development of more effective therapeutic strategies for treatments of diseases involving disconnection of axons, such as spinal cord injury and stroke. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 29 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 21% |
Student > Master | 5 | 17% |
Professor > Associate Professor | 5 | 17% |
Student > Bachelor | 4 | 14% |
Researcher | 3 | 10% |
Other | 2 | 7% |
Unknown | 4 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 11 | 38% |
Neuroscience | 7 | 24% |
Agricultural and Biological Sciences | 3 | 10% |
Medicine and Dentistry | 1 | 3% |
Unknown | 7 | 24% |