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Proline Isomerization of Histone H3 Regulates Lysine Methylation and Gene Expression

Overview of attention for article published in Cell, September 2006
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)

Mentioned by

patent
1 patent
wikipedia
4 Wikipedia pages

Citations

dimensions_citation
212 Dimensions

Readers on

mendeley
262 Mendeley
citeulike
2 CiteULike
connotea
1 Connotea
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Title
Proline Isomerization of Histone H3 Regulates Lysine Methylation and Gene Expression
Published in
Cell, September 2006
DOI 10.1016/j.cell.2006.07.026
Pubmed ID
Authors

Christopher J. Nelson, Helena Santos-Rosa, Tony Kouzarides

Abstract

The cis-trans isomerization of proline serves as a regulatory switch in signaling pathways. We identify the proline isomerase Fpr4, a member of the FK506 binding protein family in Saccharomyces cerevisiae, as an enzyme which binds the amino-terminal tail of histones H3 and H4 and catalyses the isomerization of H3 proline P30 and P38 in vitro. We show that P38 is necessary for methylation of K36 and that isomerization by Fpr4 inhibits the ability of Set2 to methylate H3 K36 in vitro. These results suggest that the conformational state of P38, controlled by Fpr4, is important for methylation of H3K36 by Set2. Consistent with such an antagonistic role, abrogation of Fpr4 catalytic activity in vivo results in increased levels of H3K36 methylation and delayed transcriptional induction kinetics of specific genes in yeast. These results identify proline isomerization as a novel noncovalent histone modification that regulates transcription and provides evidence for crosstalk between histone lysine methylation and proline isomerization.

Mendeley readers

The data shown below were compiled from readership statistics for 262 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 2%
United Kingdom 5 2%
Brazil 1 <1%
Italy 1 <1%
Norway 1 <1%
South Africa 1 <1%
India 1 <1%
France 1 <1%
Belgium 1 <1%
Other 1 <1%
Unknown 244 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 70 27%
Researcher 61 23%
Student > Bachelor 32 12%
Student > Master 24 9%
Professor > Associate Professor 17 6%
Other 39 15%
Unknown 19 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 132 50%
Biochemistry, Genetics and Molecular Biology 64 24%
Chemistry 19 7%
Medicine and Dentistry 10 4%
Neuroscience 4 2%
Other 13 5%
Unknown 20 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2021.
All research outputs
#3,487,479
of 17,358,590 outputs
Outputs from Cell
#7,902
of 15,570 outputs
Outputs of similar age
#59,866
of 297,373 outputs
Outputs of similar age from Cell
#105
of 142 outputs
Altmetric has tracked 17,358,590 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15,570 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 42.3. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 297,373 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 142 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.