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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Trimethylsilyl tag for probing protein–ligand interactions by NMR
|
|---|---|
| Published in |
Journal of Biomolecular NMR, March 2018
|
| DOI | 10.1007/s10858-018-0173-6 |
| Pubmed ID | |
| Authors |
Walter Becker, Luke A. Adams, Bim Graham, Gabriel E. Wagner, Klaus Zangger, Gottfried Otting, Christoph Nitsche |
| Abstract |
Protein-ligand titrations can readily be monitored with a trimethylsilyl (TMS) tag. Owing to the intensity, narrow line shape and unique chemical shift of a TMS group, dissociation constants can be determined from straightforward 1D 1H-NMR spectra not only in the fast but also in the slow exchange limit. The tag is easily attached to cysteine residues and a sensitive reporter of ligand binding also at sites where it does not interfere with ligand binding or catalytic efficiency of the target protein. Its utility is demonstrated for the Zika virus NS2B-NS3 protease and the human prolyl isomerase FK506 binding protein. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 1 | 33% |
| Switzerland | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 28 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 21% |
| Student > Ph. D. Student | 6 | 21% |
| Student > Bachelor | 4 | 14% |
| Student > Master | 3 | 11% |
| Other | 2 | 7% |
| Other | 3 | 11% |
| Unknown | 4 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 6 | 21% |
| Medicine and Dentistry | 4 | 14% |
| Chemistry | 3 | 11% |
| Agricultural and Biological Sciences | 2 | 7% |
| Immunology and Microbiology | 1 | 4% |
| Other | 6 | 21% |
| Unknown | 6 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2019.
All research outputs
#13,348,775
of 23,028,364 outputs
Outputs from Journal of Biomolecular NMR
#329
of 616 outputs
Outputs of similar age
#167,025
of 332,402 outputs
Outputs of similar age from Journal of Biomolecular NMR
#2
of 2 outputs
Altmetric has tracked 23,028,364 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 616 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 332,402 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.