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Structure and expression of the three MHC-linked HSP70 genes

Overview of attention for article published in Immunogenetics, October 1990
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Title
Structure and expression of the three MHC-linked HSP70 genes
Published in
Immunogenetics, October 1990
DOI 10.1007/bf00187095
Pubmed ID
Authors

Caroline M. Milner, R. Duncan Campbell

Abstract

A duplicated locus encoding the major heat shock-induced protein HSP70 is located in the major histocompatibility complex (MHC) class III region 92 kilobases (kb) telomeric to the C2 gene. Nucleotide sequence analysis of the two intronless genes, HSP70-1 and HSP70-2, has shown that they encode an identical protein product of 641 amino acids. A third intronless gene, HSP70-Hom, has also been identified 4 kb telomeric to the HSP70-1 gene. This encodes a more basic protein of 641 amino acids which has 90% sequence similarity with HSP70-1. In order to investigate the expression of the three (MHC)-linked HSP70 genes individually by northern blot analysis, we have isolated locus-specific probes from the 3' untranslated regions of the genes. The HSP70-1 and HSP70-2 genes have been shown to be expressed at high levels as a approximately 2.4 kb mRNA in cells heat-shocked at 42 degrees C. HSP70-1 is also expressed constitutively at very low levels. The HSP70-Hom gene, which has no heat shock consensus sequence in its 5' flanking sequence, is expressed as a approximately 3 kb mRNA at low levels both constitutively and following heat shock.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 2%
Unknown 49 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 18%
Student > Master 8 16%
Researcher 7 14%
Student > Doctoral Student 5 10%
Professor > Associate Professor 4 8%
Other 7 14%
Unknown 10 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 14 28%
Agricultural and Biological Sciences 13 26%
Medicine and Dentistry 6 12%
Chemistry 2 4%
Neuroscience 2 4%
Other 3 6%
Unknown 10 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2024.
All research outputs
#7,454,066
of 22,788,370 outputs
Outputs from Immunogenetics
#323
of 1,202 outputs
Outputs of similar age
#4,517
of 15,867 outputs
Outputs of similar age from Immunogenetics
#3
of 7 outputs
Altmetric has tracked 22,788,370 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
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