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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons
|
|---|---|
| Published in |
Nature Communications, March 2018
|
| DOI | 10.1038/s41467-018-03538-9 |
| Pubmed ID | |
| Authors |
Erik Södersten, Konstantinos Toskas, Vilma Rraklli, Katarina Tiklova, Åsa K. Björklund, Markus Ringnér, Thomas Perlmann, Johan Holmberg |
| Abstract |
The brain is composed of hundreds of different neuronal subtypes, which largely retain their identity throughout the lifespan of the organism. The mechanisms governing this stability are not fully understood, partly due to the diversity and limited size of clinically relevant neuronal populations, which constitute a technical challenge for analysis. Here, using a strategy that allows for ChIP-seq combined with RNA-seq in small neuronal populations in vivo, we present a comparative analysis of permissive and repressive histone modifications in adult midbrain dopaminergic neurons, raphe nuclei serotonergic neurons, and embryonic neural progenitors. Furthermore, we utilize the map generated by our analysis to show that the transcriptional response of midbrain dopaminergic neurons following 6-OHDA or methamphetamine injection is characterized by increased expression of genes with promoters dually marked by H3K4me3/H3K27me3. Our study provides an in vivo genome-wide analysis of permissive/repressive histone modifications coupled to gene expression in these rare neuronal subtypes. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 17% |
| Sweden | 1 | 17% |
| United States | 1 | 17% |
| United Kingdom | 1 | 17% |
| Unknown | 2 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 50% |
| Scientists | 2 | 33% |
| Science communicators (journalists, bloggers, editors) | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 86 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 24 | 28% |
| Student > Ph. D. Student | 16 | 19% |
| Student > Bachelor | 10 | 12% |
| Student > Doctoral Student | 6 | 7% |
| Student > Master | 5 | 6% |
| Other | 11 | 13% |
| Unknown | 14 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 27 | 31% |
| Agricultural and Biological Sciences | 17 | 20% |
| Neuroscience | 13 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Chemistry | 2 | 2% |
| Other | 6 | 7% |
| Unknown | 19 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 April 2018.
All research outputs
#7,301,234
of 23,028,364 outputs
Outputs from Nature Communications
#36,656
of 47,425 outputs
Outputs of similar age
#127,893
of 330,380 outputs
Outputs of similar age from Nature Communications
#979
of 1,205 outputs
Altmetric has tracked 23,028,364 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 47,425 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.9. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,380 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
We're also able to compare this research output to 1,205 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.