Title |
Isolation and Characterization of Full and Truncated Forms of Human Breast Carcinoma Protein BA46 from Human Milk Fat Globule Membranes
|
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Published in |
The Protein Journal, February 1998
|
DOI | 10.1023/a:1022531500370 |
Pubmed ID | |
Authors |
Maria Gabriella Giuffrida, Maria Cavaletto, Carlo Giunta, Amedeo Conti, Jasminka Godovac-Zimmermann |
Abstract |
We have isolated and characterized two proteins of 50 and 30 kDa from human milk fat globule membranes of healthy donors. N-terminal and internal sequencing revealed that the 50-kDa protein is the full-length human breast carcinoma protein BA46 that is highly expressed in human breast tumors. The 30-kDa protein is a truncated form of protein BA46 which consists of the C-terminal factor V/VIII-like domain of BA46 and which appears to anchor BA46 to the milk fat globule membrane. Defective release of the epidermal growth factor domain containing a surface RGD motif may be related to involvement of BA46 in breast cancer. |
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