RT @casey6r0wn: Intronic repeat expansion at ABCA7 leads to alternative splicing, increased non-functional transcripts, increased Alzheimer…
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RT @casey6r0wn: Intronic repeat expansion at ABCA7 leads to alternative splicing, increased non-functional transcripts, increased Alzheimer…
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Intronic repeat expansion at ABCA7 leads to alternative splicing, increased non-functional transcripts, increased Alzheimer’s risk: https://t.co/wbNLGlm6sh https://t.co/VPjlEEI6r0
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Cool paper. An intronic 25 nucleotide tandem repeat in ABCA7 influences splicing and expression and inversely correlates in length with CSF Amyloid beta levels in Alzheimer's Disease. Explains the GWAS link of this gene in AD. Feels like the tip of a ver