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Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site‐directed mutagenesis

Overview of attention for article published in Febs Letters, July 2004
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Title
Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site‐directed mutagenesis
Published in
Febs Letters, July 2004
DOI 10.1016/j.febslet.2004.06.068
Pubmed ID
Authors

Andrew J Lindsay, Mary W McCaffrey

Abstract

Rab coupling protein (RCP) is a member of the Rab11-family of interacting proteins (Rab11-FIPs). Family members are characterised by their ability to interact with Rab11. This property is mediated by a conserved Rab binding domain (RBD) located at their carboxy-termini. Several Rab11-FIPs can also interact with other small GTPases. RCP interacts with Rab4 in addition to Rab11. To dissect out the individual properties of the Rab4 and Rab11 interactions with RCP, conserved amino acids within the RBD of RCP were mutated by site-directed mutagenesis. The effect of these mutations on Rab4 and Rab11 binding, and the intracellular localisation of RCP, was examined. Our results indicate that Rab11, rather than Rab4, mediates the intracellular localisation of RCP, and that the class I Rab11-FIPs compete for binding to Rab11.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 4%
Korea, Republic of 1 4%
Unknown 21 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 30%
Student > Ph. D. Student 7 30%
Student > Bachelor 3 13%
Professor > Associate Professor 3 13%
Other 1 4%
Other 1 4%
Unknown 1 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 52%
Biochemistry, Genetics and Molecular Biology 7 30%
Chemistry 2 9%
Neuroscience 1 4%
Environmental Science 1 4%
Other 0 0%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#8,534,528
of 25,371,288 outputs
Outputs from Febs Letters
#4,917
of 14,373 outputs
Outputs of similar age
#20,954
of 59,003 outputs
Outputs of similar age from Febs Letters
#47
of 109 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 14,373 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
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We're also able to compare this research output to 109 others from the same source and published within six weeks on either side of this one. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.