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Rab Coupling Protein Associates with Phagosomes and Regulates Recycling from the Phagosomal Compartment

Overview of attention for article published in Traffic, August 2004
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Rab Coupling Protein Associates with Phagosomes and Regulates Recycling from the Phagosomal Compartment
Published in
Traffic, August 2004
DOI 10.1111/j.1600-0854.2004.00220.x
Pubmed ID

María T. Damiani, Martín Pavarotti, Natalia Leiva, Andrew J. Lindsay, Mary W. McCaffrey, Maria I. Colombo


The Rab coupling protein (RCP) is a recently identified novel protein that belongs to the Rab11-FIP family. RCP interacts specifically with Rab4 and Rab11, small guanosine-5'-triphosphatases that function as regulators along the endosomal recycling pathway. We used fluorescence confocal microscopy and biochemical approaches to evaluate the participation of RCP during particle uptake and phagosome maturation. In macrophages, RCP is predominantly membrane-bound and displays a punctuate vesicular pattern throughout the cytoplasm. RCP is mainly associated with transferrin-containing structures and Rab11-labeled endosomes. Overexpression of H13, the carboxyl-terminal region of RCP that contains the Rab binding domain, results in an abnormal endosomal compartment. Interestingly, we found that RCP is associated as discrete patches or protein domains to early phagosomal membranes. In macrophages, overexpression of full-length RCP stimulates recycling from the phagosomal compartment, whereas overexpression of H13 diminishes this vesicular transport step. It is likely that acting as an intermediate between Rab4 and Rab11, RCP regulates membrane flux along the phagocytic pathway via recycling events.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Uruguay 1 2%
Unknown 59 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 42%
Student > Doctoral Student 6 10%
Student > Bachelor 6 10%
Professor 6 10%
Researcher 4 7%
Other 10 17%
Unknown 3 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 42%
Biochemistry, Genetics and Molecular Biology 17 28%
Immunology and Microbiology 7 12%
Medicine and Dentistry 2 3%
Arts and Humanities 2 3%
Other 3 5%
Unknown 4 7%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
of 24,602,766 outputs
Outputs from Traffic
of 1,256 outputs
Outputs of similar age
of 62,356 outputs
Outputs of similar age from Traffic
of 8 outputs
Altmetric has tracked 24,602,766 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,256 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 62,356 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.