Title |
Reversible Self-Assembled Monolayers (rSAMs) as Robust and Fluidic Lipid Bilayer Mimics
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Published in |
Langmuir, March 2018
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DOI | 10.1021/acs.langmuir.8b00226 |
Pubmed ID | |
Authors |
Sing Yee Yeung, Thomas Ederth, Guoqing Pan, Judita Cicėnaitė, Marité Cárdenas, Thomas Arnebrant, Börje Sellergren |
Abstract |
Lipid bilayers, forming the outer barrier of cells, display a wide array of proteins and carbohydrates for modulating interfacial biological interactions. Formed by the spontaneous self-assembly of lipid molecules, these bilayers feature liquid crystalline order, while retaining a high degree of lateral mobility. Studies of these dynamic phenomena have been hampered by the fragility and instability of corresponding biomimetic cell membrane models. Here, we present the construct of a series of oligoethylene glycol-terminated reversible self-assembled monolayers (rSAMs) featuring lipid-bilayer-like fluidity, while retaining air and protein stability and resistance. These robust and ordered layers were prepared by simply immersing a carboxylic acid-terminated self-assembled monolayer into 5-50 μM aqueous ω-(4-ethylene glycol-phenoxy)-α-(4-amidinophenoxy)decane solutions. It is anticipated that this new class of robust and fluidic two-dimensional biomimetic surfaces will impact the design of rugged cell surface mimics and high-performance biosensors. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
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Unknown | 28 | 100% |
Demographic breakdown
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Student > Ph. D. Student | 8 | 29% |
Researcher | 5 | 18% |
Professor | 3 | 11% |
Student > Bachelor | 3 | 11% |
Student > Master | 1 | 4% |
Other | 1 | 4% |
Unknown | 7 | 25% |
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Chemistry | 9 | 32% |
Biochemistry, Genetics and Molecular Biology | 4 | 14% |
Physics and Astronomy | 2 | 7% |
Engineering | 2 | 7% |
Medicine and Dentistry | 1 | 4% |
Other | 2 | 7% |
Unknown | 8 | 29% |