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Synthesis of a 3-methyluridine phosphoramidite to investigate the role of methylation in a ribosomal RNA hairpin

Overview of attention for article published in Bioorganic & Medicinal Chemistry, February 2002
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (61st percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

patent
2 patents

Citations

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12 Dimensions

Readers on

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13 Mendeley
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Title
Synthesis of a 3-methyluridine phosphoramidite to investigate the role of methylation in a ribosomal RNA hairpin
Published in
Bioorganic & Medicinal Chemistry, February 2002
DOI 10.1016/s0968-0896(01)00283-8
Pubmed ID
Authors

Helen M.-P Chui, May Meroueh, Stephen A Scaringe, Christine S Chow

Abstract

The synthesis of a 5'-O-BzH-2'-O-ACE-protected-3-methyluridine phosphoramidite is reported [BzH, benzhydryloxy-bis(trimethylsilyloxy)silyl; ACE, bis(2-acetoxyethoxy)methyl]. The phosphoramidite was employed in solid-phase RNA synthesis to generate a series of RNA hairpins containing single or multiple modifications, including the common nucleoside pseudouridine. Three 19-nucleotide hairpin RNAs that represent the 1920-loop region (G(1906)-C(1924)) of Escherichia coli 23S ribosomal RNA were generated. Modifications were present at positions 1911, 1915, and 1917. The stabilities and structures of the three RNAs were examined by using thermal melting, circular dichroism, and NMR spectroscopy

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 31%
Professor > Associate Professor 2 15%
Student > Ph. D. Student 1 8%
Student > Master 1 8%
Other 1 8%
Other 4 31%
Readers by discipline Count As %
Chemistry 8 62%
Biochemistry, Genetics and Molecular Biology 2 15%
Agricultural and Biological Sciences 2 15%
Unspecified 1 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2010.
All research outputs
#3,518,525
of 12,272,194 outputs
Outputs from Bioorganic & Medicinal Chemistry
#1,769
of 5,113 outputs
Outputs of similar age
#99,897
of 269,761 outputs
Outputs of similar age from Bioorganic & Medicinal Chemistry
#8
of 63 outputs
Altmetric has tracked 12,272,194 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,113 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,761 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.