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Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved‐like phenotype

Overview of attention for article published in EMBO Reports, August 2005
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (66th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

wikipedia
1 Wikipedia page

Citations

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38 Dimensions

Readers on

mendeley
28 Mendeley
citeulike
1 CiteULike
Title
Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved‐like phenotype
Published in
EMBO Reports, August 2005
DOI 10.1038/sj.embor.7400458
Pubmed ID
Authors

Costanza Ballarò, Sara Ceccarelli, Cecilia Tiveron, Laura Tatangelo, Anna Maria Salvatore, Oreste Segatto, Stefano Alemà

Abstract

Although it has been clearly established that negative feedback loops have a fundamental role in the regulation of epidermal growth factor receptor (EGFR) signalling in flies, their role in the regulation of mammalian EGFR has been inferred only recently from in vitro studies. Here, we report on the forced expression of RALT/MIG-6, a negative feedback regulator of ErbB receptors, in mouse skin. A RALT transgene driven by the K14 promoter generated a dose-dependent phenotype resembling that caused by hypomorphic and antimorphic Egfr alleles-that is, wavy coat, curly whiskers and open eyes at birth. Ex vivo keratinocytes from K14-RALT mice showed reduced biochemical and biological responses when stimulated by ErbB ligands. Conversely, knockdown of RALT by RNA interference enhanced ErbB mitogenic signalling. Thus, RALT behaves as a suppressor of EGFR signalling in mouse skin.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 4%
Australia 1 4%
Unknown 26 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 36%
Researcher 10 36%
Professor 2 7%
Other 1 4%
Student > Bachelor 1 4%
Other 2 7%
Unknown 2 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 43%
Medicine and Dentistry 7 25%
Biochemistry, Genetics and Molecular Biology 4 14%
Computer Science 1 4%
Neuroscience 1 4%
Other 1 4%
Unknown 2 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2007.
All research outputs
#3,559,816
of 12,380,306 outputs
Outputs from EMBO Reports
#1,147
of 2,377 outputs
Outputs of similar age
#79,696
of 270,432 outputs
Outputs of similar age from EMBO Reports
#25
of 44 outputs
Altmetric has tracked 12,380,306 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,377 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.9. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,432 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.