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Mendeley readers
| Title |
Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription
|
|---|---|
| Published in |
Retrovirology, July 2005
|
| DOI | 10.1186/1742-4690-2-47 |
| Pubmed ID | |
| Authors |
Tatyana Ammosova, Kareem Washington, Zufan Debebe, John Brady, Sergei Nekhai |
| Abstract |
HIV-1 Tat protein recruits human positive transcription elongation factor P-TEFb, consisting of CDK9 and cyclin T1, to HIV-1 transactivation response (TAR) RNA. CDK9 is maintained in dephosphorylated state by TFIIH and undergo phosphorylation upon the dissociation of TFIIH. Thus, dephosphorylation of CDK9 prior to its association with HIV-1 preinitiation complex might be important for HIV-1 transcription. Others and we previously showed that protein phosphatase-2A and protein phosphatase-1 regulates HIV-1 transcription. In the present study we analyze relative contribution of PP2A and PP1 to dephosphorylation of CDK9 and to HIV-1 transcription in vitro and in vivo. |
Mendeley readers
The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 4% |
| Unknown | 26 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 37% |
| Student > Master | 4 | 15% |
| Student > Doctoral Student | 3 | 11% |
| Student > Ph. D. Student | 2 | 7% |
| Professor | 2 | 7% |
| Other | 2 | 7% |
| Unknown | 4 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 10 | 37% |
| Biochemistry, Genetics and Molecular Biology | 7 | 26% |
| Immunology and Microbiology | 2 | 7% |
| Medicine and Dentistry | 2 | 7% |
| Computer Science | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 4 | 15% |