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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Off-target-free gene delivery by affinity-purified receptor-targeted viral vectors
|
|---|---|
| Published in |
Nature Communications, February 2015
|
| DOI | 10.1038/ncomms7246 |
| Pubmed ID | |
| Authors |
Robert C. Münch, Anke Muth, Alexander Muik, Thorsten Friedel, Julia Schmatz, Birgit Dreier, Alexandra Trkola, Andreas Plückthun, Hildegard Büning, Christian J. Buchholz |
| Abstract |
We describe receptor-targeted adeno-associated viral (AAV) vectors that allow genetic modification of rare cell types ex vivo and in vivo while showing no detectable off-targeting. Displaying designed ankyrin repeat proteins (DARPins) on the viral capsid and carefully depleting DARPin-deficient particles, AAV vectors were made specific for Her2/neu, EpCAM or CD4. A single intravenous administration of vector targeted to the tumour antigen Her2/neu was sufficient to track 75% of all tumour sites and to extend survival longer than the cytostatic antibody Herceptin. CD4-targeted AAVs hit human CD4-positive cells present in spleen of a humanized mouse model, while CD8-positive cells as well as liver or other off-target organs remained unmodified. Mimicking conditions of circulating tumour cells, EpCAM-AAV detected single tumour cells in human blood opening the avenue for tumour stem cell tracking. Thus, the approach developed here delivers genes to target cell types of choice with antibody-like specificity. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 211 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 3 | 1% |
| United Kingdom | 2 | <1% |
| Korea, Republic of | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 203 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 53 | 25% |
| Researcher | 37 | 18% |
| Student > Master | 28 | 13% |
| Student > Bachelor | 17 | 8% |
| Student > Doctoral Student | 10 | 5% |
| Other | 23 | 11% |
| Unknown | 43 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 57 | 27% |
| Biochemistry, Genetics and Molecular Biology | 55 | 26% |
| Medicine and Dentistry | 16 | 8% |
| Immunology and Microbiology | 12 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 3% |
| Other | 20 | 9% |
| Unknown | 44 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 42. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 January 2024.
All research outputs
#882,121
of 23,757,348 outputs
Outputs from Nature Communications
#14,499
of 49,574 outputs
Outputs of similar age
#13,081
of 361,175 outputs
Outputs of similar age from Nature Communications
#176
of 700 outputs
Altmetric has tracked 23,757,348 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 49,574 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.3. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 361,175 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 700 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.