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Changes in synovial fluid biomarkers and clinical efficacy of intra-articular injections of hyaluronic acid for patients with knee osteoarthritis

Overview of attention for article published in Journal of Experimental Orthopaedics, December 2014
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (62nd percentile)

Mentioned by

patent
1 patent

Citations

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10 Dimensions

Readers on

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28 Mendeley
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Title
Changes in synovial fluid biomarkers and clinical efficacy of intra-articular injections of hyaluronic acid for patients with knee osteoarthritis
Published in
Journal of Experimental Orthopaedics, December 2014
DOI 10.1186/s40634-014-0016-7
Pubmed ID
Authors

Yoshihiro Kusayama, Yasushi Akamatsu, Ken Kumagai, Hideo Kobayashi, Masato Aratake, Tomoyuki Saito

Abstract

The changes in synovial fluid biomarkers after intra-articular injection of hyarulonic acid (IA HA) remain controversial. We investigate the changes in the properties of synovial fluid (SF) and clinical symptoms before the first and fifth IA HA. A total of 73 patients (73 knees) with symptomatic knee osteoarthritis were treated with five weekly intra-articular injections of HA and 55 patients (55 knees) were analyzed. The SF total volume, viscosity, and levels of HA, chondroitin 4-sulfate (C4S), chondroitin 6-sulfate (C6S), keratin sulfate, and interleukin (IL)-6 were measured before the first and fifth injections. Clinical evaluations were performed using the American Knee Society score for physician-based outcome measurements and Knee injury and Osteoarthritis Outcome Score for patient-based outcome measurements before the first and fifth injections. The SF viscosity and levels of HA were significantly increased, and the total SF volume and levels of chondroitin 4-sulfate, chondroitin 6-sulfate, and interleukin-6 were significantly decreased. The physician-based and patient-based outcome scores were improved. Our findings speculate that HA injections significantly modulate levels of intra articular biomarkers which may indicate beneficial effect for articular cartilage and synovium membrane.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 21%
Researcher 5 18%
Student > Ph. D. Student 4 14%
Student > Bachelor 3 11%
Professor > Associate Professor 2 7%
Other 6 21%
Unknown 2 7%
Readers by discipline Count As %
Medicine and Dentistry 7 25%
Biochemistry, Genetics and Molecular Biology 5 18%
Agricultural and Biological Sciences 4 14%
Unspecified 2 7%
Engineering 2 7%
Other 5 18%
Unknown 3 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2017.
All research outputs
#3,214,803
of 11,477,928 outputs
Outputs from Journal of Experimental Orthopaedics
#12
of 43 outputs
Outputs of similar age
#92,025
of 252,633 outputs
Outputs of similar age from Journal of Experimental Orthopaedics
#2
of 2 outputs
Altmetric has tracked 11,477,928 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 43 research outputs from this source. They receive a mean Attention Score of 4.1. This one scored the same or higher as 31 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,633 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.