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NCAM (CD56) Expression in keratin-producing odontogenic cysts: aberrant expression in KCOT

Overview of attention for article published in Head & Face Medicine, February 2015
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Title
NCAM (CD56) Expression in keratin-producing odontogenic cysts: aberrant expression in KCOT
Published in
Head & Face Medicine, February 2015
DOI 10.1186/s13005-015-0060-2
Pubmed ID
Authors

Beatriz Vera-Sirera, Leopoldo Forner-Navarro, Francisco Vera-Sempere

Abstract

To investigate immunohistochemically the expression of neural cell adhesion molecule (NCAM), which has been identified as a signaling receptor with frequent reactivity in ameloblastomas (AB), in a series of keratin-producing odontogenic cysts (KPOCs). Immunohistochemical expression of NCAM, using a monoclonal antibody, was determined in a series of 58 KPOCs comprising 12 orthokeratinized odontogenic cysts (OOCs) and 46 keratocystic odontogenic tumors (KCOTs), corresponding to 40 non-syndromic KCOT (NS-KCOTs) and 6 syndromic KCOT (S-KCOTs), associated with nevic basocellular syndrome (NBCS). NCAM expression was negative in all OOCs, but 36.45% of KCOTs exhibited focal and heterogeneous expression at the basal cell level, as well as in basal budding areas and the basal cells of daughter cysts. The latter two locations were especially applicable to S-KCOTs, with focal NCAM reactivity occurring in 66.66% of cases. Aberrant NCAM expression, in KCOTs but especially in S-KCOTs, together with its immunomorphological location, suggests that this adhesion molecule and signaling receptor plays a role in the pathogenesis of KCOTs, with a probable impact on lesional recurrence.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 2 33%
Student > Master 1 17%
Student > Bachelor 1 17%
Other 1 17%
Professor 1 17%
Other 0 0%
Readers by discipline Count As %
Medicine and Dentistry 5 83%
Engineering 1 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 February 2015.
All research outputs
#3,367,195
of 4,751,646 outputs
Outputs from Head & Face Medicine
#101
of 158 outputs
Outputs of similar age
#119,060
of 170,120 outputs
Outputs of similar age from Head & Face Medicine
#5
of 9 outputs
Altmetric has tracked 4,751,646 research outputs across all sources so far. This one is in the 16th percentile – i.e., 16% of other outputs scored the same or lower than it.
So far Altmetric has tracked 158 research outputs from this source. They receive a mean Attention Score of 1.4. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
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We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.