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Human Cdc45 is a proliferation-associated antigen

Overview of attention for article published in FEBS Journal, July 2007
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (66th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

patent
3 patents

Citations

dimensions_citation
41 Dimensions

Readers on

mendeley
30 Mendeley
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Title
Human Cdc45 is a proliferation-associated antigen
Published in
FEBS Journal, July 2007
DOI 10.1111/j.1742-4658.2007.05900.x
Pubmed ID
Authors

S. Pollok, C. Bauerschmidt, J. Sänger, H.-P. Nasheuer, F. Grosse

Abstract

Cell division cycle protein 45 (Cdc45) plays a critical role in DNA replication to ensure that chromosomal DNA is replicated only once per cell cycle. We analysed the expression of human Cdc45 in proliferating and nonproliferating cells. Our findings show that Cdc45 protein is absent from long-term quiescent, terminally differentiated and senescent human cells, although it is present throughout the cell cycle of proliferating cells. Moreover, Cdc45 is much less abundant than the minichromosome maintenance (Mcm) proteins in human cells, supporting the concept that origin binding of Cdc45 is rate limiting for replication initiation. We also show that the Cdc45 protein level is consistently higher in human cancer-derived cells compared with primary human cells. Consequently, tumour tissue is preferentially stained using Cdc45-specific antibodies. Thus, Cdc45 expression is tightly associated with proliferating cell populations and Cdc45 seems to be a promising candidate for a novel proliferation marker in cancer cell biology.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 3%
Italy 1 3%
Unknown 28 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 30%
Student > Ph. D. Student 8 27%
Student > Master 3 10%
Student > Postgraduate 2 7%
Professor 2 7%
Other 4 13%
Unknown 2 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 47%
Biochemistry, Genetics and Molecular Biology 5 17%
Neuroscience 2 7%
Immunology and Microbiology 2 7%
Social Sciences 1 3%
Other 3 10%
Unknown 3 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 August 2017.
All research outputs
#3,240,200
of 11,541,953 outputs
Outputs from FEBS Journal
#611
of 3,107 outputs
Outputs of similar age
#76,789
of 255,773 outputs
Outputs of similar age from FEBS Journal
#5
of 62 outputs
Altmetric has tracked 11,541,953 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,107 research outputs from this source. They receive a mean Attention Score of 2.8. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 255,773 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.