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X Demographics
Mendeley readers
Attention Score in Context
| Title |
FGF-2 regulation of neurogenesis in adult hippocampus after brain injury
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, April 2001
|
| DOI | 10.1073/pnas.101034998 |
| Pubmed ID | |
| Authors |
Shinichi Yoshimura, Yasushi Takagi, Jun Harada, Tetsuyuki Teramoto, Sunu S. Thomas, Christian Waeber, Joanna C. Bakowska, Xandra O. Breakefield, Michael A. Moskowitz |
| Abstract |
Fibroblast growth factor-2 (FGF-2) promotes proliferation of neuroprogenitor cells in culture and is up-regulated within brain after injury. Using mice genetically deficient in FGF-2 (FGF-2(-/-) mice), we addressed the importance of endogenously generated FGF-2 on neurogenesis within the hippocampus, a structure involved in spatial, declarative, and contextual memory, after seizures or ischemic injury. BrdUrd incorporation was used to mark dividing neuroprogenitor cells and NeuN expression to monitor their differentiation into neurons. In the wild-type strain, hippocampal FGF-2 increased after either kainic acid injection or middle cerebral artery occlusion, and the numbers of BrdUrd/NeuN-positive cells significantly increased on days 9 and 16 as compared with the controls. In FGF-2(-/-) mice, BrdUrd labeling was attenuated after kainic acid or middle cerebral artery occlusion, as was the number of neural cells colabeled with both BrdUrd and NeuN. After FGF-2(-/-) mice were injected intraventricularly with a herpes simplex virus-1 amplicon vector carrying FGF-2 gene, the number of BrdUrd-labeled cells increased significantly to values equivalent to wild-type littermates after kainate seizures. These results indicate that endogenously synthesized FGF-2 is necessary and sufficient to stimulate proliferation and differentiation of neuroprogenitor cells in the adult hippocampus after brain insult. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 2% |
| Indonesia | 1 | <1% |
| France | 1 | <1% |
| Brazil | 1 | <1% |
| Canada | 1 | <1% |
| Mexico | 1 | <1% |
| Argentina | 1 | <1% |
| Russia | 1 | <1% |
| United States | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 115 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 23% |
| Researcher | 21 | 17% |
| Student > Bachelor | 17 | 14% |
| Student > Master | 15 | 12% |
| Professor > Associate Professor | 9 | 7% |
| Other | 28 | 22% |
| Unknown | 6 | 5% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 47 | 38% |
| Neuroscience | 24 | 19% |
| Medicine and Dentistry | 19 | 15% |
| Biochemistry, Genetics and Molecular Biology | 9 | 7% |
| Engineering | 6 | 5% |
| Other | 10 | 8% |
| Unknown | 10 | 8% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2023.
All research outputs
#5,271,026
of 25,483,400 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#46,955
of 103,183 outputs
Outputs of similar age
#6,878
of 42,613 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#148
of 494 outputs
Altmetric has tracked 25,483,400 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 103,183 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.5. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 42,613 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 494 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.