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FGF-2 regulation of neurogenesis in adult hippocampus after brain injury

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, April 2001
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • Good Attention Score compared to outputs of the same age and source (69th percentile)

Mentioned by

twitter
2 tweeters
patent
7 patents

Citations

dimensions_citation
385 Dimensions

Readers on

mendeley
125 Mendeley
Summary Twitter Patents Dimensions citations
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Title
FGF-2 regulation of neurogenesis in adult hippocampus after brain injury
Published in
Proceedings of the National Academy of Sciences of the United States of America, April 2001
DOI 10.1073/pnas.101034998
Pubmed ID
11320217
Authors

Shinichi Yoshimura, Yasushi Takagi, Jun Harada, Tetsuyuki Teramoto, Sunu S. Thomas, Christian Waeber, Joanna C. Bakowska, Xandra O. Breakefield, Michael A. Moskowitz

Abstract

Fibroblast growth factor-2 (FGF-2) promotes proliferation of neuroprogenitor cells in culture and is up-regulated within brain after injury. Using mice genetically deficient in FGF-2 (FGF-2(-/-) mice), we addressed the importance of endogenously generated FGF-2 on neurogenesis within the hippocampus, a structure involved in spatial, declarative, and contextual memory, after seizures or ischemic injury. BrdUrd incorporation was used to mark dividing neuroprogenitor cells and NeuN expression to monitor their differentiation into neurons. In the wild-type strain, hippocampal FGF-2 increased after either kainic acid injection or middle cerebral artery occlusion, and the numbers of BrdUrd/NeuN-positive cells significantly increased on days 9 and 16 as compared with the controls. In FGF-2(-/-) mice, BrdUrd labeling was attenuated after kainic acid or middle cerebral artery occlusion, as was the number of neural cells colabeled with both BrdUrd and NeuN. After FGF-2(-/-) mice were injected intraventricularly with a herpes simplex virus-1 amplicon vector carrying FGF-2 gene, the number of BrdUrd-labeled cells increased significantly to values equivalent to wild-type littermates after kainate seizures. These results indicate that endogenously synthesized FGF-2 is necessary and sufficient to stimulate proliferation and differentiation of neuroprogenitor cells in the adult hippocampus after brain insult.

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Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 2%
Indonesia 1 <1%
France 1 <1%
Brazil 1 <1%
Canada 1 <1%
Mexico 1 <1%
Argentina 1 <1%
Russia 1 <1%
United States 1 <1%
Other 0 0%
Unknown 115 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 29 23%
Researcher 21 17%
Student > Bachelor 17 14%
Student > Master 15 12%
Professor > Associate Professor 9 7%
Other 28 22%
Unknown 6 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 47 38%
Neuroscience 24 19%
Medicine and Dentistry 18 14%
Biochemistry, Genetics and Molecular Biology 9 7%
Engineering 6 5%
Other 11 9%
Unknown 10 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2023.
All research outputs
#4,713,865
of 23,567,572 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#44,345
of 99,702 outputs
Outputs of similar age
#6,258
of 40,689 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#146
of 485 outputs
Altmetric has tracked 23,567,572 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 99,702 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.7. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 40,689 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 485 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.

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