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High-Affinity Inhibitors of Human NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships

Overview of attention for article published in PLOS ONE, November 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

Mentioned by

patent
4 patents
wikipedia
2 Wikipedia pages

Citations

dimensions_citation
26 Dimensions

Readers on

mendeley
47 Mendeley
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Title
High-Affinity Inhibitors of Human NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships
Published in
PLOS ONE, November 2010
DOI 10.1371/journal.pone.0013719
Pubmed ID
Authors

Frank H. Niesen, Lena Schultz, Ajit Jadhav, Chitra Bhatia, Kunde Guo, David J. Maloney, Ewa S. Pilka, Minghua Wang, Udo Oppermann, Tom D. Heightman, Anton Simeonov

Abstract

15-Hydroxyprostaglandin dehydrogenase (15-PGDH, EC 1.1.1.141) is the key enzyme for the inactivation of prostaglandins, regulating processes such as inflammation or proliferation. The anabolic pathways of prostaglandins, especially with respect to regulation of the cyclooxygenase (COX) enzymes have been studied in detail; however, little is known about downstream events including functional interaction of prostaglandin-processing and -metabolizing enzymes. High-affinity probes for 15-PGDH will, therefore, represent important tools for further studies.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 6%
United Kingdom 2 4%
Romania 1 2%
Unknown 41 87%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 32%
Researcher 12 26%
Student > Bachelor 5 11%
Student > Postgraduate 3 6%
Student > Doctoral Student 2 4%
Other 6 13%
Unknown 4 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 30%
Chemistry 13 28%
Biochemistry, Genetics and Molecular Biology 7 15%
Medicine and Dentistry 3 6%
Immunology and Microbiology 2 4%
Other 4 9%
Unknown 4 9%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 July 2023.
All research outputs
#2,658,291
of 24,041,016 outputs
Outputs from PLOS ONE
#33,419
of 206,339 outputs
Outputs of similar age
#10,579
of 103,505 outputs
Outputs of similar age from PLOS ONE
#193
of 986 outputs
Altmetric has tracked 24,041,016 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 206,339 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 103,505 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 986 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.