Title |
Dicer regulates Xist promoter methylation in ES cells indirectly through transcriptional control of Dnmt3a
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Published in |
Epigenetics & Chromatin, October 2008
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DOI | 10.1186/1756-8935-1-2 |
Pubmed ID | |
Authors |
Tatyana B Nesterova, Bilyana C Popova, Bradley S Cobb, Sara Norton, Claire E Senner, Y Amy Tang, Thomas Spruce, Tristan A Rodriguez, Takashi Sado, Matthias Merkenschlager, Neil Brockdorff |
Abstract |
X chromosome inactivation is the mechanism used in mammals to achieve dosage compensation of X-linked genes in XX females relative to XY males. Chromosome silencing is triggered in cis by expression of the non-coding RNA Xist. As such, correct regulation of the Xist gene promoter is required to establish appropriate X chromosome activity both in males and females. Studies to date have demonstrated co-transcription of an antisense RNA Tsix and low-level sense transcription prior to onset of X inactivation. The balance of sense and antisense RNA is important in determining the probability that a given Xist allele will be expressed, termed the X inactivation choice, when X inactivation commences. |
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