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Dicer regulates Xist promoter methylation in ES cells indirectly through transcriptional control of Dnmt3a

Overview of attention for article published in Epigenetics & Chromatin, January 2008
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (72nd percentile)

Mentioned by

wikipedia
1 Wikipedia page

Citations

dimensions_citation
66 Dimensions

Readers on

mendeley
101 Mendeley
citeulike
2 CiteULike
connotea
3 Connotea
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Title
Dicer regulates Xist promoter methylation in ES cells indirectly through transcriptional control of Dnmt3a
Published in
Epigenetics & Chromatin, January 2008
DOI 10.1186/1756-8935-1-2
Pubmed ID
Authors

Tatyana B Nesterova, Bilyana C Popova, Bradley S Cobb, Sara Norton, Claire E Senner, Y Amy Tang, Thomas Spruce, Tristan A Rodriguez, Takashi Sado, Matthias Merkenschlager, Neil Brockdorff

Abstract

X chromosome inactivation is the mechanism used in mammals to achieve dosage compensation of X-linked genes in XX females relative to XY males. Chromosome silencing is triggered in cis by expression of the non-coding RNA Xist. As such, correct regulation of the Xist gene promoter is required to establish appropriate X chromosome activity both in males and females. Studies to date have demonstrated co-transcription of an antisense RNA Tsix and low-level sense transcription prior to onset of X inactivation. The balance of sense and antisense RNA is important in determining the probability that a given Xist allele will be expressed, termed the X inactivation choice, when X inactivation commences.

Mendeley readers

The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 3%
Spain 2 2%
Austria 1 <1%
Pakistan 1 <1%
Germany 1 <1%
Japan 1 <1%
Unknown 92 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 25%
Researcher 19 19%
Professor 12 12%
Student > Master 11 11%
Student > Bachelor 10 10%
Other 19 19%
Unknown 5 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 58 57%
Biochemistry, Genetics and Molecular Biology 29 29%
Computer Science 2 2%
Arts and Humanities 1 <1%
Business, Management and Accounting 1 <1%
Other 3 3%
Unknown 7 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 April 2012.
All research outputs
#816,707
of 3,635,048 outputs
Outputs from Epigenetics & Chromatin
#53
of 107 outputs
Outputs of similar age
#25,246
of 96,343 outputs
Outputs of similar age from Epigenetics & Chromatin
#12
of 13 outputs
Altmetric has tracked 3,635,048 research outputs across all sources so far. This one has received more attention than most of these and is in the 63rd percentile.
So far Altmetric has tracked 107 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 96,343 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.