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Dicer regulates Xist promoter methylation in ES cells indirectly through transcriptional control of Dnmt3a

Overview of attention for article published in Epigenetics & Chromatin, October 2008
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3 Wikipedia pages

Citations

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77 Dimensions

Readers on

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118 Mendeley
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2 CiteULike
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3 Connotea
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Title
Dicer regulates Xist promoter methylation in ES cells indirectly through transcriptional control of Dnmt3a
Published in
Epigenetics & Chromatin, October 2008
DOI 10.1186/1756-8935-1-2
Pubmed ID
Authors

Tatyana B Nesterova, Bilyana C Popova, Bradley S Cobb, Sara Norton, Claire E Senner, Y Amy Tang, Thomas Spruce, Tristan A Rodriguez, Takashi Sado, Matthias Merkenschlager, Neil Brockdorff

Abstract

X chromosome inactivation is the mechanism used in mammals to achieve dosage compensation of X-linked genes in XX females relative to XY males. Chromosome silencing is triggered in cis by expression of the non-coding RNA Xist. As such, correct regulation of the Xist gene promoter is required to establish appropriate X chromosome activity both in males and females. Studies to date have demonstrated co-transcription of an antisense RNA Tsix and low-level sense transcription prior to onset of X inactivation. The balance of sense and antisense RNA is important in determining the probability that a given Xist allele will be expressed, termed the X inactivation choice, when X inactivation commences.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 118 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 3%
Spain 2 2%
Austria 1 <1%
Germany 1 <1%
Pakistan 1 <1%
Japan 1 <1%
Unknown 109 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 28 24%
Researcher 18 15%
Student > Master 15 13%
Student > Bachelor 12 10%
Professor 11 9%
Other 22 19%
Unknown 12 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 57 48%
Biochemistry, Genetics and Molecular Biology 35 30%
Immunology and Microbiology 2 2%
Arts and Humanities 2 2%
Computer Science 2 2%
Other 6 5%
Unknown 14 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2021.
All research outputs
#7,454,298
of 22,789,076 outputs
Outputs from Epigenetics & Chromatin
#312
of 566 outputs
Outputs of similar age
#32,436
of 91,727 outputs
Outputs of similar age from Epigenetics & Chromatin
#3
of 4 outputs
Altmetric has tracked 22,789,076 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 566 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 91,727 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.