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Mendeley readers
Attention Score in Context
| Title |
PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation
|
|---|---|
| Published in |
Oncogene, January 2005
|
| DOI | 10.1038/sj.onc.1208410 |
| Pubmed ID | |
| Authors |
Mei Yu, Sabine Schreek, Christa Cerni, Chantal Schamberger, Krzysztof Lesniewicz, Elzbieta Poreba, Jörg Vervoorts, Gesa Walsemann, Joachim Grötzinger, Elisabeth Kremmer, Yasmin Mehraein, Jürgen Mertsching, Regine Kraft, Matthias Austen, Juliane Lüscher-Firzlaff, Bernhard Lüscher |
| Abstract |
The proto-oncoprotein c-Myc functions as a transcriptional regulator that controls different aspects of cell behavior, including proliferation, differentiation, and apoptosis. In addition, Myc proteins have the potential to transform cells and are deregulated in the majority of human cancers. Several Myc-interacting factors have been described that mediate part of Myc's functions in the control of cell behavior. Here, we describe the isolation of a novel 150 kDa protein, designated PARP-10, that interacts with Myc. PARP-10 possesses domains with homology to RNA recognition motifs and to poly(ADP-ribose) polymerases (PARP). Molecular modeling and biochemical analysis define a PARP domain that is capable of ADP-ribosylating PARP-10 itself and core histones, but neither Myc nor Max. PARP-10 is localized to the nuclear and cytoplasmic compartments that is controlled at least in part by a Leu-rich nuclear export sequence (NES). Functionally, PARP-10 inhibits c-Myc- and E1A-mediated cotransformation of rat embryo fibroblasts, a function that is independent of PARP activity but that depends on a functional NES. Together, our findings define a novel PARP enzyme involved in the control of cell proliferation. |
Mendeley readers
The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 93 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 22% |
| Researcher | 15 | 16% |
| Student > Master | 12 | 13% |
| Student > Bachelor | 11 | 12% |
| Professor | 5 | 5% |
| Other | 12 | 13% |
| Unknown | 19 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 27 | 28% |
| Biochemistry, Genetics and Molecular Biology | 25 | 26% |
| Chemistry | 8 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Medicine and Dentistry | 3 | 3% |
| Other | 6 | 6% |
| Unknown | 23 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2024.
All research outputs
#2,213,955
of 23,445,423 outputs
Outputs from Oncogene
#528
of 10,762 outputs
Outputs of similar age
#5,869
of 143,386 outputs
Outputs of similar age from Oncogene
#1
of 145 outputs
Altmetric has tracked 23,445,423 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,762 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 143,386 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 145 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.